
Michael V. Sofroniew, M.D., Ph.D.
Titles
Professor, Neurobiology
Member, Brain Research Institute
CTSI
Neuroengineering Training Program
Neuroscience GPB Home Area
Contact Information
Email
sofroniew@mednet.ucla.edu Phone
Lab Number:
310 206 2262
Work Phone Number: (310)794-4944
Work Phone Number: (310)794-4944
Address
Mailing Address:
Department of NeurobiologyDavid Geffen School of Medicine at UCLA
Los Angeles, CA 90095
UNITED STATES
Work Address:
Office501 Neuroscience Research Building
Los Angeles, CA 90095
UNITED STATES
Publications
A selected list of publications:
Anderson Mark A, Burda Joshua E, Ren Yilong, Ao Yan, O'Shea Timothy M, Kawaguchi Riki, Coppola Giovanni, Khakh Baljit S, Deming Timothy J, Sofroniew Michael V
Astrocyte scar formation aids central nervous system axon
regeneration
Nature,
2016; 532(7598):
195-200.
Khakh Baljit S, Sofroniew Michael V
Diversity of astrocyte functions and phenotypes in neural circuits
Nature neuroscience,
2015; 18(7):
942-52.
Sofroniew Michael V
Astrocyte barriers to neurotoxic inflammation
Nature reviews. Neuroscience,
2015; 16(5):
249-63.
Tong Xiaoping, Ao Yan, Faas Guido C, Nwaobi Sinifunanya E, Xu Ji, Haustein Martin D, Anderson Mark A, Mody Istvan, Olsen Michelle L, Sofroniew Michael V, Khakh Baljit S
Astrocyte Kir4.1 ion channel deficits contribute to neuronal
dysfunction in Huntington's disease model mice
Nature neuroscience,
2014; 17(5):
694-703.
Burda Joshua E, Sofroniew Michael V
Reactive gliosis and the multicellular response to CNS damage and
disease
Neuron,
2014; 81(2):
229-48.
Shigetomi Eiji, Bushong Eric A, Haustein Martin D, Tong Xiaoping, Jackson-Weaver Olan, Kracun Sebastian, Xu Ji, Sofroniew Michael V, Ellisman Mark H, Khakh Baljit S
Imaging calcium microdomains within entire astrocyte territories and
endfeet with GCaMPs expressed using adeno-associated viruses
The Journal of general physiology,
2013; 141(5):
633-47.
Song Bingbing, Song Jinsuk, Zhang Shanshan, Anderson Mark A, Ao Yan, Yang Chu-Ya, Deming Timothy J, Sofroniew Michael V
Sustained local delivery of bioactive nerve growth factor in the
central nervous system via tunable diblock copolypeptide hydrogel
depots
Biomaterials,
2012; 33(35):
9105-16.
Nobuta Hiroko, Ghiani Cristina A, Paez Pablo M, Spreuer Vilma, Dong Hongmei, Korsak Rose A, Manukyan Armine, Li Jiaxi, Vinters Harry V, Huang Eric J, Rowitch David H, Sofroniew Michael V, Campagnoni Anthony T, de Vellis Jean, Waschek James A
STAT3-mediated astrogliosis protects myelin development in neonatal
brain injury
Annals of neurology,
2012; 72(5):
750-65.
Hamby Mary E, Coppola Giovanni, Ao Yan, Geschwind Daniel H, Khakh Baljit S, Sofroniew Michael V
Inflammatory mediators alter the astrocyte transcriptome and calcium
signaling elicited by multiple G-protein-coupled receptors
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2012; 32(42):
14489-510.
Argaw Azeb Tadesse, Asp Linnea, Zhang Jingya, Navrazhina Kristina, Pham Trinh, Mariani John N, Mahase Sean, Dutta Dipankar J, Seto Jeremy, Kramer Elisabeth G, Ferrara Napoleone, Sofroniew Michael V, John Gareth R
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS
inflammatory disease
The Journal of clinical investigation,
2012; 122(7):
2454-68.
Cushman Jesse D, Maldonado Jose, Kwon Eunice E, Garcia A Denise, Fan Guoping, Imura Tetsuya, Sofroniew Michael V, Fanselow Michael S
Juvenile neurogenesis makes essential contributions to adult brain
structure and plays a sex-dependent role in fear memories
Frontiers in behavioral neuroscience,
2012; 6(3):
3.
Verkhratsky Alexei, Sofroniew Michael V, Messing Albee, deLanerolle Nihal C, Rempe David, RodrÃguez José Julio, Nedergaard Maiken
Neurological diseases as primary gliopathies: a reassessment of
neurocentrism
ASN neuro,
2012; 4(3):
.
Sofroniew Michael V
Transgenic techniques for cell ablation or molecular deletion to
investigate functions of astrocytes and other GFAP-expressing cell
types
Methods in molecular biology (Clifton, N.J.),
2012; 814(3):
531-44.
Tao Jifang, Wu Hao, Lin Quan, Wei Weizheng, Lu Xiao-Hong, Cantle Jeffrey P, Ao Yan, Olsen Richard W, Yang X William, Mody Istvan, Sofroniew Michael V, Sun Yi E
Deletion of astroglial Dicer causes non-cell-autonomous neuronal
dysfunction and degeneration
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2011; 31(22):
8306-19.
Wang Xiaohong, Imura Tetsuya, Sofroniew Michael V, Fushiki Shinji
Loss of adenomatous polyposis coli in Bergmann glia disrupts their
unique architecture and leads to cell nonautonomous neurodegeneration
of cerebellar Purkinje neurons
Glia,
2011; 59(6):
857-68.
Spence Rory D, Hamby Mary E, Umeda Elizabeth, Itoh Noriko, Du Sienmi, Wisdom Amy J, Cao Yuan, Bondar Galyna, Lam Jeannie, Ao Yan, Sandoval Francisco, Suriany Silvie, Sofroniew Michael V, Voskuhl Rhonda R
Neuroprotection mediated through estrogen receptor-alpha in
astrocytes
Proceedings of the National Academy of Sciences of the United States of America,
2011; 108(21):
8867-72.
Sofroniew Michael V
Neuromyelitis optica: circulating autoantibodies provoke
astrocyte-mediated neural dysfunction
Neurology,
2011; 76(14):
1202-3.
Imura Tetsuya, Wang Xiaohong, Noda Tetsuo, Sofroniew Michael V, Fushiki Shinji
Adenomatous polyposis coli is essential for both neuronal
differentiation and maintenance of adult neural stem cells in
subventricular zone and hippocampus
Stem cells (Dayton, Ohio),
2010; 28(11):
2053-64.
Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K
Oestrogen receptor beta ligand: a novel treatment to enhance
endogenous functional remyelination
Brain : a journal of neurology,
2010; 133(10):
2999-3016.
Hamby Mary E, Sofroniew Michael V
Reactive astrocytes as therapeutic targets for CNS disorders
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
2010; 7(4):
494-506.
Shigetomi Eiji, Kracun Sebastian, Sofroniew Michael V, Khakh Baljit S
A genetically targeted optical sensor to monitor calcium signals in
astrocyte processes
Nature neuroscience,
2010; 13(6):
759-66.
Sarafian Theodore A, Montes Cindy, Imura Tetsuya, Qi Jingwei, Coppola Giovanni, Geschwind Daniel H, Sofroniew Michael V
Disruption of astrocyte STAT3 signaling decreases mitochondrial
function and increases oxidative stress in vitro
PloS one,
2010; 5(3):
e9532.
Sofroniew Michael V, Vinters Harry V
Astrocytes: biology and pathology
Acta neuropathologica,
2010; 119(1):
7-35.
Sofroniew Michael V
Molecular dissection of reactive astrogliosis and glial scar
formation
Trends in neurosciences,
2009; 32(12):
638-47.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong
PTEN dosage is essential for neurofibroma development and malignant
transformation
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(46):
19479-84.
Courtine Grégoire, Gerasimenko Yury, van den Brand Rubia, Yew Aileen, Musienko Pavel, Zhong Hui, Song Bingbing, Ao Yan, Ichiyama Ronaldo M, Lavrov Igor, Roy Roland R, Sofroniew Michael V, Edgerton V Reggie
Transformation of nonfunctional spinal circuits into functional states
after the loss of brain input
Nature neuroscience,
2009; 12(10):
1333-42.
Voskuhl Rhonda R, Peterson R Scott, Song Bingbing, Ao Yan, Morales Laurie Beth J, Tiwari-Woodruff Seema, Sofroniew Michael V
Reactive astrocytes form scar-like perivascular barriers to leukocytes
during adaptive immune inflammation of the CNS
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(37):
11511-22.
Yang Chu-Ya, Song Bingbing, Ao Yan, Nowak Andrew P, Abelowitz Ryan B, Korsak Rose A, Havton Leif A, Deming Timothy J, Sofroniew Michael V
Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the
central nervous system
Biomaterials,
2009; 30(15):
2881-98.
Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong
Pten deletion in adult neural stem/progenitor cells enhances
constitutive neurogenesis
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(6):
1874-86.
Herrmann Julia E, Imura Tetsuya, Song Bingbing, Qi Jingwei, Ao Yan, Nguyen Thu K, Korsak Rose A, Takeda Kiyoshi, Akira Shizuo, Sofroniew Michael V
STAT3 is a critical regulator of astrogliosis and scar formation after
spinal cord injury
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2008; 28(28):
7231-43.
Lepore Angelo C, Dejea Christine, Carmen Jessica, Rauck Britta, Kerr Douglas A, Sofroniew Michael V, Maragakis Nicholas J
Selective ablation of proliferating astrocytes does not affect disease
outcome in either acute or chronic models of motor neuron
degeneration
Experimental neurology,
2008; 211(2):
423-32.
Shigetomi Eiji, Bowser David N, Sofroniew Michael V, Khakh Baljit S
Two forms of astrocyte calcium excitability have distinct effects on
NMDA receptor-mediated slow inward currents in pyramidal neurons
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2008; 28(26):
6659-63.
Otis Thomas S, Sofroniew Michael V
Glia get excited
Nature neuroscience,
2008; 11(4):
379-80.
Courtine Gregoire, Song Bingbing, Roy Roland R, Zhong Hui, Herrmann Julia E, Ao Yan, Qi Jingwei, Edgerton V Reggie, Sofroniew Michael V
Recovery of supraspinal control of stepping via indirect propriospinal
relay connections after spinal cord injury
Nature medicine,
2008; 14(1):
69-74.
Savidge Tor C, Sofroniew Michael V, Neunlist Michel
Starring roles for astroglia in barrier pathologies of gut and brain
Laboratory investigation; a journal of technical methods and pathology,
2007; 87(8):
731-6.
Savidge Tor C, Newman Paul, Pothoulakis Charalabos, Ruhl Anne, Neunlist Michel, Bourreille Arnaud, Hurst Roger, Sofroniew Michael V
Enteric glia regulate intestinal barrier function and inflammation via
release of S-nitrosoglutathione
Gastroenterology,
2007; 132(4):
1344-58.
Saxe Michael D, Malleret Gaël, Vronskaya Svetlana, Mendez Indira, Garcia A Denise, Sofroniew Michael V, Kandel Eric R, Hen René
Paradoxical influence of hippocampal neurogenesis on working memory
Proceedings of the National Academy of Sciences of the United States of America,
2007; 104(11):
4642-6.
Saxe Michael D, Battaglia Fortunato, Wang Jing-Wen, Malleret Gael, David Denis J, Monckton James E, Garcia A Denise R, Sofroniew Michael V, Kandel Eric R, Santarelli Luca, Hen René, Drew Michael R
Ablation of hippocampal neurogenesis impairs contextual fear
conditioning and synaptic plasticity in the dentate gyrus
Proceedings of the National Academy of Sciences of the United States of America,
2006; 103(46):
17501-6.
Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV.
Essential protective roles of reactive astrocytes in traumatic brain injury,
Brain,
2006; 129(Pt 10):
2761-72.
Imura Tetsuya, Nakano Ichiro, Kornblum Harley I, Sofroniew Michael V
Phenotypic and functional heterogeneity of GFAP-expressing cells in
vitro: differential expression of LeX/CD15 by GFAP-expressing
multipotent neural stem cells and non-neurogenic astrocytes
Glia,
2006; 53(3):
277-93.
Sofroniew Michael V
Reactive astrocytes in neural repair and protection
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry,
2005; 11(5):
400-7.
Nakano Ichiro, Paucar Andres A, Bajpai Ruchi, Dougherty Joseph D, Zewail Amani, Kelly Theresa K, Kim Kevin J, Ou Jing, Groszer Matthias, Imura Tetsuya, Freije William A, Nelson Stanley F, Sofroniew Michael V, Wu Hong, Liu Xin, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent
neural progenitor proliferation
The Journal of cell biology,
2005; 170(3):
413-27.
Garcia A Denise R, Doan Ngan B, Imura Tetsuya, Bush Toby G, Sofroniew Michael V
GFAP-expressing progenitors are the principal source of constitutive
neurogenesis in adult mouse forebrain
Nature neuroscience,
2004; 7(11):
1233-41.
Faulkner Jill R, Herrmann Julia E, Woo Michael J, Tansey Keith E, Doan Ngan B, Sofroniew Michael V
Reactive astrocytes protect tissue and preserve function after spinal
cord injury
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2004; 24(9):
2143-55.
Morshead Cindi M, Garcia A Denize, Sofroniew Michael V, van Der Kooy Derek
The ablation of glial fibrillary acidic protein-positive cells from
the adult central nervous system results in the loss of forebrain
neural stem cells but not retinal stem cells
The European journal of neuroscience,
2003; 18(1):
76-84.
Imura Tetsuya, Kornblum Harley I, Sofroniew Michael V
The predominant neural stem cell isolated from postnatal and adult
forebrain but not early embryonic forebrain expresses GFAP
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2003; 23(7):
2824-32.
Sofroniew, MV Howe, CL Mobley, WC
Nerve growth factor signaling, neuroprotection, and neural repair
Annual review of neuroscience. ,
2001; 24:
1217-81.
Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV.
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice,
Neuron,
1999; 23(2):
297-308.
Lam, HH Bhardwaj, A O'Connell, MT Hanley, DF Traystman, RJ Sofroniew, MV
Nerve growth factor rapidly suppresses basal, NMDA-evoked, and AMPA-evoked nitric oxide synthase activity in rat hippocampus in vivo
Proceedings of the National Academy of Sciences of the United States of America. ,
1998; 95(18):
10926-31.
Kimonedes, V.G., Svendsen, C.N., Sofroniew, M.V. and Herbert, J.
Dehydroepiandrosterone (DHEA) protects hippocampal neurons against NMDA-induced neurotoxicity,
,
1998; Proc. Natl. Acad. Sci. USA 95:
1852-1857 .
Bush, TG Savidge, TC Freeman, TC Cox, HJ Campbell, EA Mucke, L Johnson, MH Sofroniew, MV
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
Cell. ,
1998; 93(2):
189-201.