Theresa Harrison

BRI member leads study showing how a molecular receptor helps restore brain function after 'silent stroke'

S. Thomas Carmichael, M.D., Ph.D., professor of neurology at the David Geffen School of Medicine, is senior author of a five year study that shows how the brain can be repaired and brain function recovered after a stroke in animals.

The discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, which is a major form of dementia. "Despite how common and devastating white matter stroke is, there has been little understanding of how the brain responds and if it can recover," Dr. Carmichael said. "By studying the mechanisms and limitations of brain repair in this type of stroke, we will be able to identify new therapies to prevent disease progression and enhance recovery."

The study was published in the Proceedings of the National Academy of Sciences (December 27th, 2016).

More details here.

Image left: New brain cells replace those destroyed by stroke in animals: immature cells are green, more mature cells are red and fully mature cells are orange.


June Image of the Month

Image of the Month

Traverse section of day 4 chicken embryo labeled with antibodies against Lhx2/9 (red), IsI1I (green), and LhxI/5 (blue). These transcription factors are establishing both different classes of neurons in the spinal cord and distinct mesodermal derivatives in the proximal distal limb and embryonic kidneys.


Image by Madeline Andrews from the laboratory of Samantha Butler, Ph.D.





In the News Image

Announcing the Inaugural Recipients of the BRI Knaub Fellowship in Multiple Sclerosis Research 

Funded by a generous gift from the Knaub Unitrust, established by Richard and Suzanne Knaub, the fellowships support Postdoctoral or Predoctoral Fellows pursuing projects related to Multiple Sclerosis research at UCLA. The fellowships recognize young scientists who exemplify trainee excellence, innovation, and a multidisciplinary approach to MS research. 

The inaugural Knaub Fellows are Stefano Lepore, Ph.D. from the laboratory of Allan Mackenzie-Graham, Ph.D.; and David DiTullio from the laboratory of S. Thomas Carmichael, M.D., Ph.D. 

"We want to express our sincere gratitude to the Knaub family for this generous gift which will enable these young researchers to contribute to translational research related to understanding and treating MS," said BRI Director Christopher Evans.

Learn more about the 2017 Knaub Fellows here.



The Neuroscience Interdepartmental Program


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Upcoming Events

Joint Seminars in Neuroscience Lecture Series

Tuesday, February 28, 2017

Dr. Diana Bautista, Ph.D.
Associate Professor
Department of Cell and Developmental Biology
Division of Neurobiology
University of California, Berkeley

"Neural Control of Itch and Inflammation"

Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin.  Patients suffering from severe AD eventually progress to develop asthma and allergic rhinitis, in a process known as the "atopic march."  Signaling between epithelial cells and innate immune cells via the cytokine Thymic Stromal Lymphopoietin (TSLP) was thought to drive AD and the atopic march.  However, our recent studies suggest that sensory neurons also express TSLP Receptors and that direct signaling between keratinocytes and sensory neurons via TSLP can promote itch and inflammation.  Indeed, crosstalk among epithelial cells, immune cells and somatosensory neurons is an emerging theme in a variety of inflammatory diseases, including chronic itch, allergic itch, asthma, psoriasis, and colitis.  However, the molecular mechanisms by which sensory neurons promote atopic or other inflammatory diseases are unknown.,  I will discuss our recent studies on the role of TSLP in somatosensory neuron signaling, and the role of neuron-immune cell and neuron-epithelial cell signaling in the development of itch and inflammation.


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