Theresa Harrison

BRI member leads study showing how a molecular receptor helps restore brain function after 'silent stroke'

S. Thomas Carmichael, M.D., Ph.D., professor of neurology at the David Geffen School of Medicine, is senior author of a five year study that shows how the brain can be repaired and brain function recovered after a stroke in animals.

The discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, which is a major form of dementia. "Despite how common and devastating white matter stroke is, there has been little understanding of how the brain responds and if it can recover," Dr. Carmichael said. "By studying the mechanisms and limitations of brain repair in this type of stroke, we will be able to identify new therapies to prevent disease progression and enhance recovery."

The study was published in the Proceedings of the National Academy of Sciences (December 27th, 2016).

More details here.

Image left: New brain cells replace those destroyed by stroke in animals: immature cells are green, more mature cells are red and fully mature cells are orange.

 

June Image of the Month

Image of the Month

Traverse section of day 4 chicken embryo labeled with antibodies against Lhx2/9 (red), IsI1I (green), and LhxI/5 (blue). These transcription factors are establishing both different classes of neurons in the spinal cord and distinct mesodermal derivatives in the proximal distal limb and embryonic kidneys.

 

Image by Madeline Andrews from the laboratory of Samantha Butler, Ph.D.

 

 

 

 

In the News Image

Announcing the Inaugural Recipients of the BRI Knaub Fellowship in Multiple Sclerosis Research 

Funded by a generous gift from the Knaub Unitrust, established by Richard and Suzanne Knaub, the fellowships support Postdoctoral or Predoctoral Fellows pursuing projects related to Multiple Sclerosis research at UCLA. The fellowships recognize young scientists who exemplify trainee excellence, innovation, and a multidisciplinary approach to MS research. 

The inaugural Knaub Fellows are Stefano Lepore, Ph.D. from the laboratory of Allan Mackenzie-Graham, Ph.D.; and David DiTullio from the laboratory of S. Thomas Carmichael, M.D., Ph.D. 

"We want to express our sincere gratitude to the Knaub family for this generous gift which will enable these young researchers to contribute to translational research related to understanding and treating MS," said BRI Director Christopher Evans.

Learn more about the 2017 Knaub Fellows here.

 

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Joint Seminars in Neuroscience Lecture Series

Tuesday, January 24, 2017

Dr. Marlene Cohen, Ph.D.
Associate Professor
Department of Neuroscience and Center for the Neural Basis of Cognition
University of Pittsburgh
Pittsburgh, PA

"Multineuron Approaches to Studying Attention"

Visual attention, which allows observers to select the important parts of a complex visual scene for further processing, is known to improve perception and modulate the responses of neurons in visual cortex.  The way that attention modulates the responses of single neurons is consistent with two hypothesis: 1) that attention improves the way that visual information is encoded in groups of neurons, and 2) that attention selectively improves the way that important visual information is communicated to downstream areas for further processing.  I will describe results from a combination of multielectrode recordings in multiple areas of visual cortex, computational modeling, and causal manipulations that shed light on the role of both mechanisms in perception.

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