Etchi image

The Brain Research Institute is hosting a new solo exhibition by Israeli artist Etchi Werner-Nyiri

HIVE MIND

Art inspired by the human brain

February 3rd - June 3rd, 2016
Mondays to Fridays, 8am to 6pm
Gonda Building Foyer

Visitors welcome

Member Interactome

New Feature: 

The BRI Member Interactome, mapping over 40 years of publications and collaborations between our researchers. 
Visit it here.

Feburary Image of the Month

Image of the Month

Diencephalic clusters of Vmat2 positive neurons in the developing zebrafish larva. A fixed Vmat2:GFP transgenic larva was glycerol-cleared and a Z-stack of images was collected with a confocal microscope and a projection image was made from the stack and pseudocolored for depth.

Image by Sataree Khuansuwan from the laboratory of Jeff Bronstein.

 

Project Synapse Flyer

Attention UCLA Neuroscience Postdoctoral Scholars

You are invited to join Project Synapse, a new postdoctoral group offering a strong network of colleagues, career development workshops, and opportunities to participate in K-12 outreach and teaching activities. 

The next meeting is scheduled for Tuesday, February 16th at 4:30pm in the Wasserman building, room 434. It will include a workshop entitled "How to Succeed in Academic Interviews and Job Talks", and a discussion of preparations for Brain Awareness Week, which will be held March 7th - 11th. 

More information here.

 

Elaine Hsiao, PhD

Introducing the BRI's New Member

ELAINE HSIAO, PhD, ASSISTANT PROFESSOR, INTEGRATIVE BIOLOGY AND PHYSIOLOGY

Elaine Hsiao investigates the neurobiology of disease, with a special focus in the interactions between the brain and microbial cells in the gut. Her work is situated at the interface of neurobiology, immunology and microbiology and uses an integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?

Hsiao’s studies have given new insights into the way commensal microbes regulate complex behaviors such as anxiety, learning and memory and appetite. “What if we could, without a single invasive procedure, treat disorders like autism, depression and MS with microbe-based therapeutics,” Hsiao says.

For more information about the Hsiao lab, please visit here.

For information about the BRI's new affinity group, the UCLA Microbiome Center, please visit here.

NSIDP

The Interdepartmental Program for Neuroscience 

About

Graduate Program

Undergraduate Program

Upcoming Events

JOINT SEMINARS IN NEUROSCIENCE

TUESDAY, FEBRUARY 9nd, 2016 AT 12:00 NOON

Speaker: GREG BASHAW, PhD, Professor
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Host: SAMANTHA BUTLER, PhD, Assistant Professor 
Department of Neurobiology, UCLA

Title: "To cross or not to cross: molecular mechanisms that regulate axon guidance at the midline"
12:00pm  Neuroscience Research Building (NRB) Auditorium, UCLA

Dr Bashaw's research explores a fundamental problem in neurobiology: how axons in the developing nervous system successfully navigate to their correct targets. Understanding the mechanisms that mediate axon guidance provides important insight into how the nervous system is correctly wired during development and may have implications for therapeutic approaches to developmental brain disorders and nerve regeneration. Achieving this understanding requires unraveling the molecular logic that ensures the proper expression and localization of axon guidance cues and receptors, and elucidating the signaling events that regulate the growth cone cytoskeleton in response to guidance receptor activation. 

Research in Dr Bashaw's laboratory addresses the dynamics of axon guidance receptor expression and signaling, and exploits the powerful genetic and molecular approaches available in Drosophila. In particular, the group studies the Slit ligand and Roundabout receptors, and the Netrin ligand and DCC/UNC5 receptors -- two important evolutionary conserved ligand/receptor systems that contribute to proper connectivity in both the vertebrate and invertebrate nervous systems. These molecules are also known to influence neuronal and mesodermal cell migration, suggesting that determining their function may have broad implications for understanding diseases of nervous system development, many of which have their root in defective cell migration and/or axon guidance. 

Dr Bashaw has also discovered that in addition to its canonical role in signaling locally to regulate growth cone movement and morphology, the Frazzled/DCC receptor can also act as a transcription factor to regulate gene expression. In this context, the receptor is cleaved to generate a soluble intracellular domain that can translocate to the nucleus where it activates transcription of key target genes.

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