The UCLA Joint Seminars in Neuroscience Presents - Wieland Huttner, Ph.D.

Tuesday, October 27, 2020 - 12:00pm

The UCLA Joint Seminars in Neuroscience Presents - Wieland Huttner, Ph.D.

"Neural Stem Cell, Human-Specific Genes, and Neocortex Expansion in Development and Human Evolution"

Wieland Huttner, Ph.D.
Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstrasse 108
01307 Dresden, Germany

Abstract: Two major classes of neural stem and progenitor cells (NPCs) in developing neocortex can be distinguished. First, NPCs that reside in the ventricular zone (VZ), i.e. neuroepithelial cells, apical (or ventricular) radial glia (aRG), and apical intermediate progenitors, collectively referred to as apical progenitors (APs). Second, NPCs that reside in the subventricular zone (SVZ), i.e. basal (or outer) radial glia (bRG) and basal intermediate progenitors, collectively referred to as basal progenitors (BPs). Neocortex expansion is thought to be linked to an increased abundance and proliferative capacity of BPs.
The following topics will be addressed.
1. The role of the human-specific gene ARHGAP11B in BP amplification.
2. The finding that the ability of ARHGAP11B to amplify BPs is based on a single C-to-G base substitution.
3. The ability of ARHGAP11B to expand the neocortex of a non-human primate, the common marmoset.
4. The localization of ARHGAP11B in mitochondria of NPCs and its action to promote glutaminolysis.
5. The increase in BP proliferative capacity due to the changes in their morphology in the course of neocortex evolution.

Host: Dr. Ye Zhang

Location: Zoom Meeting

Seminar Registration: https://uclahs.zoom.us/meeting/register/tJUudOqorT8tE9VkNyAQR_Z23wa5xYFj...

Important access information will be provided upon registration.