The UCLA Joint Seminars in Neuroscience Presents - Shernaz X. Bamji, Ph.D.

Tuesday, February 16, 2021 - 12:00pm

The UCLA Joint Seminars in Neuroscience Presents - Shernaz X. Bamji, Ph.D.

"Regulation of Synapse Formation and Plasticity by Palmitoylating Enzymes"

Shernaz X. Bamji, Ph.D.
Professor, Department of Cellular and Physiological Sciences;
Associate Director, Djavad Mowafaghian Center for Brain Health
University of British Columbia

Abstract: Palmitoylation is the most common post-translational lipid modification in the brain and has been shown to be important for neurite outgrowth, spine and synapse formation, synaptic transmission, and synaptic plasticity. While ~10% of all proteins in the genome are substrates for palmitoylation, a striking 41% of all synaptic proteins can be palmitoylated. Enzymes that mediate palmitoylation have been shown to be associated with brain disorders, further underscoring the importance of palmitoylation in brain development and function. My talk will demonstrate the importance for palmitoylation in regulating synapse formation and plasticity and how disruption of this process can be linked to intellectual disability and seizures.

Host: Dr. Samantha Butler

Zoom Seminar Registration: https://uclahs.zoom.us/meeting/register/tJMofuqtrzMiG9Q26wDQrpoeNgZ_ymj7...

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