The UCLA Joint Seminars in Neuroscience Presents - Samantha Butler, Ph.D.

Tuesday, February 9, 2021 - 12:00pm
The Eleanor Leslie Term Chair in Pioneering Brain Research

The UCLA Joint Seminars in Neuroscience Presents - Samantha Butler, Ph.D.

"Molecular Pathways That Accelerate the Regeneration of Axons Following Nerve Injury"

Samantha Butler, Ph.D.
Professor, Eleanor I. Leslie Chair in Pioneering Brain Research
Department of Neurobiology
David Geffen School of Medicine at UCLA

Abstract: Regenerating axons often have to grow considerable distances to reestablish circuits, making functional recovery a lengthy process. One solution to this problem would be to co-opt the “temporal” guidance mechanisms that control the rate of axon growth during development to accelerate the rate at which nerves regenerate in adults. Our studies have shown that the loss of Limk1, a negative regulator of cofilin, accelerates the rate of axon growth from both spinal commissural and motor neurons during development. The regulation of cofilin activity also appears to be an acute response to nerve injury in the peripheral nervous system. Within hours of a sciatic nerve injury, the level of phosphorylated cofilin dramatically increases at the lesion site, in a Limk1-dependent manner. This response may be a major constraint on the rate of peripheral nerve regeneration. Proof-of-principle experiments show that elevating cofilin activity, through the loss of Limk1, results in faster sciatic nerve growth, and improved recovery of some sensory and motor function.

Host: Dr. Felix Schweizer

Zoom Seminar Registration: https://uclahs.zoom.us/meeting/register/tJMofuqtrzMiG9Q26wDQrpoeNgZ_ymj7...

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