Biography
Stephen Young grew up in Kansas and obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University-St. Louis, he did internal medicine training at UCSF and cardiology training at UCSD. He then embarked on a career in basic science. He did postdoctoral research training in lipid metabolism at UCSD with Dr. Joseph Witztum and then worked at a UCSF-affiliated research institute for 17 years. Along the way, he became an expert in using genetically modified mice to investigate the gene function in health and disease. Currently, his laboratory studies an endothelial cell protein required for plasma triglyceride metabolism and diseases of the nuclear envelope. His laboratory has a strong track record in developing the careers of young scientists. Dr. Young has received multiple awards and is a member of the National Academy of Sciences.
Publications
A selected list of publications:
Lee John M, Nobumori Chika, Tu Yiping, Choi Catherine, Yang Shao H, Jung Hea-Jin, Vickers Timothy A, Rigo Frank, Bennett C Frank, Young Stephen G, Fong Loren G
Modulation of LMNA splicing as a strategy to treat prelamin A
diseases
The Journal of clinical investigation,
2016; 126(4):
1592-602.
Mysling Simon, Kristensen Kristian Kølby, Larsson Mikael, Beigneux Anne P, Gårdsvoll Henrik, Fong Loren G, Bensadouen André, Jørgensen Thomas Jd, Young Stephen G, Ploug Michael
The acidic domain of the endothelial membrane protein GPIHBP1
stabilizes lipoprotein lipase activity by preventing unfolding of its
catalytic domain
eLife,
2016; 5(2):
e12095.
Yang Shao H, Procaccia Shiri, Jung Hea-Jin, Nobumori Chika, Tatar Angelica, Tu Yiping, Bayguinov Yulia R, Hwang Sung Jin, Tran Deanna, Ward Sean M, Fong Loren G, Young Stephen G
Mice that express farnesylated versions of prelamin A in neurons
develop achalasia
Human molecular genetics,
2015; 24(10):
2826-40.
Jung Hea-Jin, Tatar Angelica, Tu Yiping, Nobumori Chika, Yang Shao H, Goulbourne Chris N, Herrmann Harald, Fong Loren G, Young Stephen G
An absence of nuclear lamins in keratinocytes leads to ichthyosis,
defective epidermal barrier function, and intrusion of nuclear
membranes and endoplasmic reticulum into the nuclear chromatin
Molecular and cellular biology,
2014; 34(24):
4534-44.
Hong Cynthia, Marshall Stephanie M, McDaniel Allison L, Graham Mark, Layne Joseph D, Cai Lei, Scotti Elena, Boyadjian Rima, Kim Jason, Chamberlain Brian T, Tangirala Rajendra K, Jung Michael E, Fong Loren, Lee Richard, Young Stephen G, Temel Ryan E, Tontonoz Peter
The LXR-Idol axis differentially regulates plasma LDL levels in
primates and mice
Cell metabolism,
2014; 20(5):
910-8.
Plengpanich Wanee, Young Stephen G, Khovidhunkit Weerapan, Bensadoun André, Karnman Hirankorn, Ploug Michael, Gårdsvoll Henrik, Leung Calvin S, Adeyo Oludotun, Larsson Mikael, Muanpetch Suwanna, Charoen Supannika, Fong Loren G, Niramitmahapanya Sathit, Beigneux Anne P
Multimerization of glycosylphosphatidylinositol-anchored high density
lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia
from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain
The Journal of biological chemistry,
2014; 289(28):
19491-9.
Adeyo Oludotun, Allan Bernard B, Barnes Richard H, Goulbourne Chris N, Tatar Angelica, Tu Yiping, Young Lorraine C, Weinstein Michael M, Tontonoz Peter, Fong Loren G, Beigneux Anne P, Young Stephen G
Palmoplantar keratoderma along with neuromuscular and metabolic
phenotypes in Slurp1-deficient mice
The Journal of investigative dermatology,
2014; 134(6):
1589-98.
Lee John M, Tu Yiping, Tatar Angelica, Wu Daniel, Nobumori Chika, Jung Hea-Jin, Yoshinaga Yuko, Coffinier Catherine, de Jong Pieter J, Fong Loren G, Young Stephen G
Reciprocal knock-in mice to investigate the functional redundancy of
lamin B1 and lamin B2
Molecular biology of the cell,
2014; 25(10):
1666-75.
Goulbourne Chris N, Gin Peter, Tatar Angelica, Nobumori Chika, Hoenger Andreas, Jiang Haibo, Grovenor Chris R M, Adeyo Oludotun, Esko Jeffrey D, Goldberg Ira J, Reue Karen, Tontonoz Peter, Bensadoun André, Beigneux Anne P, Young Stephen G, Fong Loren G
The GPIHBP1-LPL complex is responsible for the margination of
triglyceride-rich lipoproteins in capillaries
Cell metabolism,
2014; 19(5):
849-60.
Csaki Lauren S, Dwyer Jennifer R, Li Xia, Nguyen Michael H K, Dewald Jay, Brindley David N, Lusis Aldons J, Yoshinaga Yuko, de Jong Pieter, Fong Loren, Young Stephen G, Reue Karen
Lipin-1 and lipin-3 together determine adiposity in vivo
Molecular metabolism,
2014; 3(2):
145-54.
Jung Hea-Jin, Nobumori Chika, Goulbourne Chris N, Tu Yiping, Lee John M, Tatar Angelica, Wu Daniel, Yoshinaga Yuko, de Jong Pieter J, Coffinier Catherine, Fong Loren G, Young Stephen G
Farnesylation of lamin B1 is important for retention of nuclear
chromatin during neuronal migration
Proceedings of the National Academy of Sciences of the United States of America,
2013; 110(21):
E1923-32.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter
IDOL stimulates clathrin-independent endocytosis and multivesicular
body-mediated lysosomal degradation of the low-density lipoprotein
receptor
Molecular and cellular biology,
2013; 33(8):
1503-14.
Chen Xiao-Wei, Wang He, Bajaj Kanika, Zhang Pengcheng, Meng Zhuo-Xian, Ma Danjun, Bai Yongsheng, Liu Hui-Hui, Adams Elizabeth, Baines Andrea, Yu Genggeng, Sartor Maureen A, Zhang Bin, Yi Zhengping, Lin Jiandie, Young Stephen G, Schekman Randy, Ginsburg David
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
secretion
eLife,
2013; 2(4):
e00444.
Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ
specifies lipid storage versus thermogenic gene programs
Cell metabolism,
2013; 17(3):
423-35.
Davies Brandon S J, Goulbourne Chris N, Barnes Richard H, Turlo Kirsten A, Gin Peter, Vaughan Sue, Vaux David J, Bensadoun André, Beigneux Anne P, Fong Loren G, Young Stephen G
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across
endothelial cells
Journal of lipid research,
2012; 53(12):
2690-7.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid
homeostasis in liver and aging cerebellum
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(37):
E2486-95.
Gin Peter, Goulbourne Chris N, Adeyo Oludotun, Beigneux Anne P, Davies Brandon S J, Tat Shelly, Voss Constance V, Bensadoun André, Fong Loren G, Young Stephen G
Chylomicronemia mutations yield new insights into interactions between
lipoprotein lipase and GPIHBP1
Human molecular genetics,
2012; 21(13):
2961-72.
Chang Sandy Y, Hudon-Miller Sarah E, Yang Shao H, Jung Hea-Jin, Lee John M, Farber Emily, Subramanian Thangaiah, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Young Stephen G, Fong Loren G
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A
accumulation in cells by inhibiting ZMPSTE24
Journal of lipid research,
2012; 53(6):
1176-82.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G
Reciprocal metabolic perturbations in the adipose tissue and liver of
GPIHBP1-deficient mice
Arteriosclerosis, thrombosis, and vascular biology,
2012; 32(2):
230-5.
Jung Hea-Jin, Coffinier Catherine, Choe Youngshik, Beigneux Anne P, Davies Brandon S J, Yang Shao H, Barnes Richard H, Hong Janet, Sun Tao, Pleasure Samuel J, Young Stephen G, Fong Loren G
Regulation of prelamin A but not lamin C by miR-9, a brain-specific
microRNA
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(7):
E423-31.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects
and distinct nuclear shape abnormalities in neurons
Molecular biology of the cell,
2011; 22(23):
4683-93.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P
GPIHBP1, an endothelial cell transporter for lipoprotein lipase
Journal of lipid research,
2011; 52(11):
1869-84.
Beigneux Anne P, Davies Brandon S J, Tat Shelly, Chen Jenny, Gin Peter, Voss Constance V, Weinstein Michael M, Bensadoun André, Pullinger Clive R, Fong Loren G, Young Stephen G
Assessing the role of the glycosylphosphatidylinositol-anchored high
density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in
binding lipoprotein lipase
The Journal of biological chemistry,
2011; 286(22):
19735-43.
Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G
Mutations in lipoprotein lipase that block binding to the endothelial
cell transporter GPIHBP1
Proceedings of the National Academy of Sciences of the United States of America,
2011; 108(19):
7980-4.
Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter
Targeted disruption of the idol gene alters cellular regulation of the
low-density lipoprotein receptor by sterols and liver x receptor
agonists
Molecular and cellular biology,
2011; 31(9):
1885-93.
Gin Peter, Beigneux Anne P, Voss Constance, Davies Brandon S J, Beckstead Jennifer A, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G
Binding preferences for GPIHBP1, a
glycosylphosphatidylinositol-anchored protein of capillary endothelial
cells
Arteriosclerosis, thrombosis, and vascular biology,
2011; 31(1):
176-82.
Bishop Joseph R, Passos-Bueno Maria Rita, Fong Loren, Stanford Kristin I, Gonzales Jon C, Yeh Erika, Young Stephen G, Bensadoun Andre, Witztum Joseph L, Esko Jeffrey D, Moulton Karen S
Deletion of the basement membrane heparan sulfate proteoglycan type
XVIII collagen causes hypertriglyceridemia in mice and humans
PloS one,
2010; 5(11):
e13919.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G
Unexpected expression pattern for
glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1)
in mouse tissues revealed by positron emission tomography scanning
The Journal of biological chemistry,
2010; 285(50):
39239-48.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G
Cholesterol intake modulates plasma triglyceride levels in
glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
Arteriosclerosis, thrombosis, and vascular biology,
2010; 30(11):
2106-13.
Hernandez Lidia, Roux Kyle J, Wong Esther Sook Miin, Mounkes Leslie C, Mutalif Rafidah, Navasankari Raju, Rai Bina, Cool Simon, Jeong Jae-Wook, Wang Honghe, Lee Hyun-Shik, Kozlov Serguei, Grunert Martin, Keeble Thomas, Jones C Michael, Meta Margarita D, Young Stephen G, Daar Ira O, Burke Brian, Perantoni Alan O, Stewart Colin L
Functional coupling between the extracellular matrix and nuclear
lamina by Wnt signaling in progeria
Developmental cell,
2010; 19(3):
413-25.
Davies Brandon S J, Barnes Richard H, Tu Yiping, Ren Shuxun, Andres Douglas A, Spielmann H Peter, Lammerding Jan, Wang Yibin, Young Stephen G, Fong Loren G
An accumulation of non-farnesylated prelamin A causes cardiomyopathy
but not progeria
Human molecular genetics,
2010; 19(13):
2682-94.
Coffinier Catherine, Jung Hea-Jin, Li Ziwei, Nobumori Chika, Yun Ui Jeong, Farber Emily A, Davies Brandon S, Weinstein Michael M, Yang Shao H, Lammerding Jan, Farahani Javad N, Bentolila Laurent A, Fong Loren G, Young Stephen G
Direct synthesis of lamin A, bypassing prelamin a processing, causes
misshapen nuclei in fibroblasts but no detectable pathology in mice
The Journal of biological chemistry,
2010; 285(27):
20818-26.
Davies Brandon S J, Beigneux Anne P, Barnes Richard H, Tu Yiping, Gin Peter, Weinstein Michael M, Nobumori Chika, Nyrén Rakel, Goldberg Ira, Olivecrona Gunilla, Bensadoun André, Young Stephen G, Fong Loren G
GPIHBP1 is responsible for the entry of lipoprotein lipase into
capillaries
Cell metabolism,
2010; 12(1):
42-52.
Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG.
Abnormal patterns of lipoprotein lipase release into the plasma in GPIHPB1-deficient mice ,
J. Biol. Chem. ,
2010; 12:
34511–34518.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells,
Proc. Natl. Acad. Sci. USA,
2010; 104:
13432-13437.
Olivecrona Gunilla, Ehrenborg Ewa, Semb Henrik, Makoveichuk Elena, Lindberg Anna, Hayden Michael R, Gin Peter, Davies Brandon S J, Weinstein Michael M, Fong Loren G, Beigneux Anne P, Young Stephen G, Olivecrona Thomas, Hernell Olle
Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in
familial chylomicronemia
Journal of lipid research,
2010; 51(6):
1535-45.
Franssen Remco, Young Stephen G, Peelman Frank, Hertecant Jozef, Sierts Jeroen A, Schimmel Alinda W M, Bensadoun André, Kastelein John J P, Fong Loren G, Dallinga-Thie Geesje M, Beigneux Anne P
Chylomicronemia with low postheparin lipoprotein lipase levels in the
setting of GPIHBP1 defects
Circulation. Cardiovascular genetics,
2010; 3(2):
169-78.
Lee Roger, Chang Sandy Y, Trinh Hung, Tu Yiping, White Andrew C, Davies Brandon S J, Bergo Martin O, Fong Loren G, Lowry William E, Young Stephen G
Genetic studies on the functional relevance of the protein
prenyltransferases in skin keratinocytes
Human molecular genetics,
2010; 19(8):
1603-17.
Weinstein Michael M, Yin Liya, Tu Yiping, Wang Xuping, Wu Xiaohui, Castellani Lawrence W, Walzem Rosemary L, Lusis Aldons J, Fong Loren G, Beigneux Anne P, Young Stephen G
Chylomicronemia elicits atherosclerosis in mice--brief report
Arteriosclerosis, thrombosis, and vascular biology,
2010; 30(1):
20-3.
Fong Loren G, Vickers Timothy A, Farber Emily A, Choi Christine, Yun Ui Jeong, Hu Yan, Yang Shao H, Coffinier Catherine, Lee Roger, Yin Liya, Davies Brandon S J, Andres Douglas A, Spielmann H Peter, Bennett C Frank, Young Stephen G
Activating the synthesis of progerin, the mutant prelamin A in
Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides
Human molecular genetics,
2009; 18(13):
2462-71.
Lee R, Chang SY, Trinh H, White AC, Bergo MO, Fong LG, Lowry WE, and Young SG.
Genetic Analysis of the Importance of the Protein Prenyltransferases in Skin Keratinocytes,
Human Molecular Gen,
2009; (19):
1603-1617.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG.
Chylomicronemia with a Mutant GPIHBP1 (Q115P) that Cannot Bind Lipoprotein Lipase. ,
Arterioscler Thromb Vasc Biol,
2009; (29):
956-962.
Beigneux Anne P, Weinstein Michael M, Davies Brandon S J, Gin Peter, Bensadoun André, Fong Loren G, Young Stephen G
GPIHBP1 and lipolysis: an update
Current opinion in lipidology,
2009; 20(3):
211-6.
Davies Brandon S J, Yang Shao H, Farber Emily, Lee Roger, Buck Suzanne B, Andres Douglas A, Spielmann H Peter, Agnew Brian J, Tamanoi Fuyuhiko, Fong Loren G, Young Stephen G
Increasing the length of progerin's isoprenyl anchor does not worsen
bone disease or survival in mice with Hutchinson-Gilford progeria
syndrome
Journal of lipid research,
2009; 50(1):
126-34.
Weinstein Michael M, Yin Liya, Beigneux Anne P, Davies Brandon S J, Gin Peter, Estrada Kristine, Melford Kristan, Bishop Joseph R, Esko Jeffrey D, Dallinga-Thie Geesje M, Fong Loren G, Bensadoun André, Young Stephen G
Abnormal patterns of lipoprotein lipase release into the plasma in
GPIHBP1-deficient mice
The Journal of biological chemistry,
2008; 283(50):
34511-8.
Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G
The expression of GPIHBP1, an endothelial cell binding site for
lipoprotein lipase and chylomicrons, is induced by peroxisome
proliferator-activated receptor-gamma
Molecular endocrinology (Baltimore, Md.),
2008; 22(11):
2496-504.
Yang SH, Andres DA, Spielmann HP, Young SG, and Fong LG.
Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated,
J. Clin. Invest,
2008; 118:
3291-3300.
Gin P, Yin L, Davies BSJ, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, and Beigneux AP
The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons,
J Biol. Chem,
2008; 283:
29554-29562.
Coffinier Catherine, Hudon Sarah E, Lee Roger, Farber Emily A, Nobumori Chika, Miner Jeffrey H, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Fong Loren G, Young Stephen G
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24
or lead to an accumulation of farnesyl-prelamin A in cells
The Journal of biological chemistry,
2008; 283(15):
9797-804.
Gin Peter, Beigneux Anne P, Davies Brandon, Young Madeline F, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G
Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to
GPIHBP1 containing a G56R amino acid substitution
Biochimica et biophysica acta,
2007; 1771(12):
1464-8.
Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG.
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons,
Cell Metabolism,
2007; 5:
279–291.
Allan Christopher M, Jung Cris J, Larsson Mikael, Heizer Patrick J, Tu Yiping, Sandoval Norma P, Dang Tiffany Ly P, Jung Rachel S, Beigneux Anne P, de Jong Pieter J, Fong Loren G, Young Stephen G
Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in
capillaries and abolishes LPL binding
Journal of lipid research,
2017; 58(7):
1453-1461.
Beigneux Anne P, Miyashita Kazuya, Ploug Michael, Blom Dirk J, Ai Masumi, Linton MacRae F, Khovidhunkit Weerapan, Dufour Robert, Garg Abhimanyu, McMahon Maureen A, Pullinger Clive R, Sandoval Norma P, Hu Xuchen, Allan Christopher M, Larsson Mikael, Machida Tetsuo, Murakami Masami, Reue Karen, Tontonoz Peter, Goldberg Ira J, Moulin Philippe, Charrière Sybil, Fong Loren G, Nakajima Katsuyuki, Young Stephen G
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
The New England journal of medicine,
2017; 376(17):
1647-1658.
Allan Christopher M, Larsson Mikael, Hu Xuchen, He Cuiwen, Jung Rachel S, Mapar Alaleh, Voss Constance, Miyashita Kazuya, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Bensadoun André, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding
of LPL to GPIHBP1
Journal of lipid research,
2016; 57(10):
1889-1898.
Wang Jiexin, Rajbhandari Prashant, Damianov Andrey, Han Areum, Sallam Tamer, Waki Hironori, Villanueva Claudio J, Lee Stephen D, Nielsen Ronni, Mandrup Susanne, Reue Karen, Young Stephen G, Whitelegge Julian, Saez Enrique, Black Douglas L, Tontonoz Peter
RNA-binding protein PSPC1 promotes the differentiation-dependent
nuclear export of adipocyte RNAs
The Journal of clinical investigation,
2017; 127(3):
987-1004.
He Cuiwen, Hu Xuchen, Jung Rachel S, Larsson Mikael, Tu Yiping, Duarte-Vogel Sandra, Kim Paul, Sandoval Norma P, Price Tara R, Allan Christopher M, Raney Brian, Jiang Haibo, Bensadoun André, Walzem Rosemary L, Kuo Richard I, Beigneux Anne P, Fong Loren G, Young Stephen G
Lipoprotein lipase reaches the capillary lumen in chickens despite an
apparent absence of GPIHBP1
JCI insight,
2017; 2(20):
1134-1136.
He Cuiwen, Hu Xuchen, Jung Rachel S, Weston Thomas A, Sandoval Norma P, Tontonoz Peter, Kilburn Matthew R, Fong Loren G, Young Stephen G, Jiang Haibo
High-resolution imaging and quantification of plasma membrane
cholesterol by NanoSIMS
Proceedings of the National Academy of Sciences of the United States of America,
2017; 114(8):
2000-2005.
Hu Xuchen, Dallinga-Thie Geesje M, Hovingh G Kees, Chang Sandy Y, Sandoval Norma P, Dang Tiffany Ly P, Fukamachi Isamu, Miyashita Kazuya, Nakajima Katsuyuki, Murakami Masami, Fong Loren G, Ploug Michael, Young Stephen G, Beigneux Anne P
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia
Journal of clinical lipidology,
2017; 11(4):
964-971.
Hu Xuchen, Sleeman Mark W, Miyashita Kazuya, Linton MacRae F, Allan Christopher M, He Cuiwen, Larsson Mikael, Tu Yiping, Sandoval Norma P, Jung Rachel S, Mapar Alaleh, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish
the binding of LPL
Journal of lipid research,
2017; 58(1):
208-215.