Stephen Young, M.D.

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Titles

Distinguished Professor, Medicine

Professor, Human Genetics

Member, Adult Cardiac Catheterization Laboratory

Biochemistry, Biophysics & Structural Biology GPB Home Area

CTSI

Center for Duchenne Muscular Dystrophy

JCCC Signal Transduction and Therapeutics Program Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Workforce Development

Faculty, Cardiology


Awards and Honors:

Ernst Jung Prize in Medicine

University of Gothenburg, Sweden Doctor Honoris Causa (Medicine)

American Heart Association Special Recognition Award in Vascular Biology

Named one of "America's Top Physicians"

American Heart Association Council on Arteriosclerosis Irvine H. Page Research Prize for Young Investigators

Certified, American Board of Clinical Lipidology

Contact Information

Email
sgyoung@mednet.ucla.edu
Phone
Fax Number: (310) 206-0865
Office Phone Number: (310) 825-4934
Address

Department Address:

UCLA Med-Cardio
650 Charles E. Young Drive South
A2-237 CHS Bldg.
Los Angeles, CA 90095
UNITED STATES

Office Address:

GONDA 4506A
695 Charles E. Young Drive South
GONDA 4506A
Los Angeles, CA 90095
UNITED STATES

Biography

Stephen Young grew up in Kansas and obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University-St. Louis, he did internal medicine training at UCSF and cardiology training at UCSD. He then embarked on a career in basic science. He did postdoctoral research training in lipid metabolism at UCSD with Dr. Joseph Witztum and then worked at the Gladstone Institute for Cardiovascular Disease for 17 years. Along the way, he became an expert in using genetically modified mice to investigate the gene function in health and disease. Currently, his laboratory studies an endothelial cell protein required for plasma triglyceride metabolism and diseases of the nuclear envelope. His laboratory has a strong track record in developing the careers of young scientists. Dr. Young has received multiple awards and is a member of the National Academy of Sciences.

Publications

Christiansen Jeffrey R, Pendse Nachiket D, Kolandaivelu Saravanan, Bergo Martin O, Young Stephen G, Ramamurthy Visvanathan   Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016; 36(18): 5107-14.
Fong Loren G, Young Stephen G, Beigneux Anne P, Bensadoun André, Oberer Monika, Jiang Haibo, Ploug Michael   GPIHBP1 and Plasma Triglyceride Metabolism Trends in endocrinology and metabolism: TEM, 2016; .
Razafsky David, Ward Candace, Potter Chloe, Zhu Wanqiu, Xue Yunlu, Kefalov Vladimir J, Fong Loren G, Young Stephen G, Hodzic Didier   Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development Molecular biology of the cell, 2016; 71(5): .
Lee John M, Nobumori Chika, Tu Yiping, Choi Catherine, Yang Shao H, Jung Hea-Jin, Vickers Timothy A, Rigo Frank, Bennett C Frank, Young Stephen G, Fong Loren G   Modulation of LMNA splicing as a strategy to treat prelamin A diseases The Journal of clinical investigation, 2016; 126(4): 1592-602.
Dijk Wieneke, Beigneux Anne P, Larsson Mikael, Bensadoun André, Young Stephen G, Kersten Sander   Angiopoietin-like 4 (ANGPTL4) promotes intracellular degradation of lipoprotein lipase in adipocytes Journal of lipid research, 2016; 10(4): .
Vergnes Laurent, Chin Robert G, de Aguiar Vallim Thomas, Fong Loren G, Osborne Timothy F, Young Stephen G, Reue Karen   SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression Journal of lipid research, 2016; 57(3): 410-21.
Allan Christopher M, Procaccia Shiri, Tran Deanna, Tu Yiping, Barnes Richard H, Larsson Mikael, Allan Bernard B, Young Lorraine C, Hong Cynthia, Tontonoz Peter, Fong Loren G, Young Stephen G, Beigneux Anne P   Palmoplantar Keratoderma in Slurp2-Deficient Mice The Journal of investigative dermatology, 2016; 136(2): 436-43.
Mysling Simon, Kristensen Kristian Kølby, Larsson Mikael, Beigneux Anne P, GÃ¥rdsvoll Henrik, Fong Loren G, Bensadouen André, Jørgensen Thomas Jd, Young Stephen G, Ploug Michael   The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain eLife, 2016; 5(2): e12095.
Brown W Virgil, Goldberg Ira J, Young Stephen G   JCL Roundtable: Hypertriglyceridemia due to defects in lipoprotein lipase function Journal of clinical lipidology, 2015; 9(3): 274-80.
Yang Shao H, Procaccia Shiri, Jung Hea-Jin, Nobumori Chika, Tatar Angelica, Tu Yiping, Bayguinov Yulia R, Hwang Sung Jin, Tran Deanna, Ward Sean M, Fong Loren G, Young Stephen G   Mice that express farnesylated versions of prelamin A in neurons develop achalasia Human molecular genetics, 2015; 24(10): 2826-40.
Rong Xin, Wang Bo, Dunham Merlow M, Hedde Per Niklas, Wong Jinny S, Gratton Enrico, Young Stephen G, Ford David A, Tontonoz Peter   Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion eLife, 2015; 4(1665): .
Beigneux Anne P, Fong Loren G, Bensadoun André, Davies Brandon S J, Oberer Monika, GÃ¥rdsvoll Henrik, Ploug Michael, Young Stephen G   GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding Circulation research, 2015; 116(4): 624-32.
Tapia Olga, Fong Loren G, Huber Michael D, Young Stephen G, Gerace Larry   Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases PloS one, 2015; 10(3): e0116196.
Jung Hea-Jin, Tatar Angelica, Tu Yiping, Nobumori Chika, Yang Shao H, Goulbourne Chris N, Herrmann Harald, Fong Loren G, Young Stephen G   An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin Molecular and cellular biology, 2014; 34(24): 4534-44.
Degagné Emilie, Pandurangan Ashok, Bandhuvula Padmavathi, Kumar Ashok, Eltanawy Abeer, Zhang Meng, Yoshinaga Yuko, Nefedov Mikhail, de Jong Pieter J, Fong Loren G, Young Stephen G, Bittman Robert, Ahmedi Yasmin, Saba Julie D   Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs The Journal of clinical investigation, 2014; 124(12): 5368-84.
Hong Cynthia, Marshall Stephanie M, McDaniel Allison L, Graham Mark, Layne Joseph D, Cai Lei, Scotti Elena, Boyadjian Rima, Kim Jason, Chamberlain Brian T, Tangirala Rajendra K, Jung Michael E, Fong Loren, Lee Richard, Young Stephen G, Temel Ryan E, Tontonoz Peter   The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice Cell metabolism, 2014; 20(5): 910-8.
Jiang Haibo, Goulbourne Chris N, Tatar Angelica, Turlo Kirsten, Wu Daniel, Beigneux Anne P, Grovenor Chris R M, Fong Loren G, Young Stephen G   High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis Journal of lipid research, 2014; 55(10): 2156-66.
Young Stephen G, Jung Hea-Jin, Lee John M, Fong Loren G   Nuclear lamins and neurobiology Molecular and cellular biology, 2014; 34(15): 2776-85.
Bensadoun André, Mottler Charlene D, Pelletier Chris, Wu Daniel, Seo Jane J, Leung Calvin S, Adeyo Oludotun, Goulbourne Chris N, Gin Peter, Fong Loren G, Young Stephen G, Beigneux Anne P   A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase Biochimica et biophysica acta, 2014; 1841(7): 970-6.
Lee John M, Jung Hea-Jin, Fong Loren G, Young Stephen G   Do lamin B1 and lamin B2 have redundant functions? Nucleus (Austin, Tex.), 2014; 5(4): 287-92.
Turlo Kirsten, Leung Calvin S, Seo Jane J, Goulbourne Chris N, Adeyo Oludotun, Gin Peter, Voss Constance, Bensadoun André, Fong Loren G, Young Stephen G, Beigneux Anne P   Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter Biochimica et biophysica acta, 2014; 1841(7): 963-9.
Plengpanich Wanee, Young Stephen G, Khovidhunkit Weerapan, Bensadoun André, Karnman Hirankorn, Ploug Michael, GÃ¥rdsvoll Henrik, Leung Calvin S, Adeyo Oludotun, Larsson Mikael, Muanpetch Suwanna, Charoen Supannika, Fong Loren G, Niramitmahapanya Sathit, Beigneux Anne P   Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain The Journal of biological chemistry, 2014; 289(28): 19491-9.
Adeyo Oludotun, Allan Bernard B, Barnes Richard H, Goulbourne Chris N, Tatar Angelica, Tu Yiping, Young Lorraine C, Weinstein Michael M, Tontonoz Peter, Fong Loren G, Beigneux Anne P, Young Stephen G   Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice The Journal of investigative dermatology, 2014; 134(6): 1589-98.
Lee John M, Tu Yiping, Tatar Angelica, Wu Daniel, Nobumori Chika, Jung Hea-Jin, Yoshinaga Yuko, Coffinier Catherine, de Jong Pieter J, Fong Loren G, Young Stephen G   Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2 Molecular biology of the cell, 2014; 25(10): 1666-75.
Goulbourne Chris N, Gin Peter, Tatar Angelica, Nobumori Chika, Hoenger Andreas, Jiang Haibo, Grovenor Chris R M, Adeyo Oludotun, Esko Jeffrey D, Goldberg Ira J, Reue Karen, Tontonoz Peter, Bensadoun André, Beigneux Anne P, Young Stephen G, Fong Loren G   The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries Cell metabolism, 2014; 19(5): 849-60.
Csaki Lauren S, Dwyer Jennifer R, Li Xia, Nguyen Michael H K, Dewald Jay, Brindley David N, Lusis Aldons J, Yoshinaga Yuko, de Jong Pieter, Fong Loren, Young Stephen G, Reue Karen   Lipin-1 and lipin-3 together determine adiposity in vivo Molecular metabolism, 2014; 3(2): 145-54.
Jung Hea-Jin, Tu Yiping, Yang Shao H, Tatar Angelica, Nobumori Chika, Wu Daniel, Young Stephen G, Fong Loren G   New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome Human molecular genetics, 2014; 23(6): 1506-15.
Im Seung-Soon, Young Stephen G, Raffatellu Manuela, Osborne Timothy F   Response to Gerlic et al Cell metabolism, 2014; 19(3): 346-7.
Csaki Lauren S, Dwyer Jennifer R, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen   Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling Progress in lipid research, 2013; 52(3): 305-16.
Jung Hea-Jin, Nobumori Chika, Goulbourne Chris N, Tu Yiping, Lee John M, Tatar Angelica, Wu Daniel, Yoshinaga Yuko, de Jong Pieter J, Coffinier Catherine, Fong Loren G, Young Stephen G   Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(21): E1923-32.
Ibrahim Mohamed X, Sayin Volkan I, Akula Murali K, Liu Meng, Fong Loren G, Young Stephen G, Bergo Martin O   Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria Science (New York, N.Y.), 2013; 110(21): .
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter   IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor Molecular and cellular biology, 2013; 33(8): 1503-14.
Chen Xiao-Wei, Wang He, Bajaj Kanika, Zhang Pengcheng, Meng Zhuo-Xian, Ma Danjun, Bai Yongsheng, Liu Hui-Hui, Adams Elizabeth, Baines Andrea, Yu Genggeng, Sartor Maureen A, Zhang Bin, Yi Zhengping, Lin Jiandie, Young Stephen G, Schekman Randy, Ginsburg David   SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion eLife, 2013; 2(4): e00444.
Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter   Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell metabolism, 2013; 17(3): 423-35.
Young Stephen G, Zechner Rudolf   Biochemistry and pathophysiology of intravascular and intracellular lipolysis Genes & development, 2013; 27(5): 459-84.
Jung Hea-Jin, Lee John M, Yang Shao H, Young Stephen G, Fong Loren G   Nuclear lamins in the brain - new insights into function and regulation Molecular neurobiology, 2013; 47(1): 290-301.
Khan Omar M, Akula Murali K, SkÃ¥len Kristina, Karlsson Christin, StÃ¥hlman Marcus, Young Stephen G, Borén Jan, Bergo Martin O   Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice Circulation, 2013; 127(7): 782-90.
Young Stephen G, Yang Shao H, Davies Brandon S J, Jung Hea-Jin, Fong Loren G   Targeting protein prenylation in progeria Science translational medicine, 2013; 5(171): 171ps3.
Davies Brandon S J, Goulbourne Chris N, Barnes Richard H, Turlo Kirsten A, Gin Peter, Vaughan Sue, Vaux David J, Bensadoun André, Beigneux Anne P, Fong Loren G, Young Stephen G   Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells Journal of lipid research, 2012; 53(12): 2690-7.
Nyrén Rakel, Chang Chuchun L, Lindström Per, Barmina Anastasia, Vorrsjö Evelina, Ali Yusuf, Juntti-Berggren Lisa, Bensadoun André, Young Stephen G, Olivecrona Thomas, Olivecrona Gunilla   Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency BMC physiology, 2012; 12(12): 14.
Zhang Li, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter   Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis Arteriosclerosis, thrombosis, and vascular biology, 2012; 32(11): 2541-6.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen   Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(37): E2486-95.
Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D   Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues Journal of lipid research, 2012; 53(9): 1920-31.
Gin Peter, Goulbourne Chris N, Adeyo Oludotun, Beigneux Anne P, Davies Brandon S J, Tat Shelly, Voss Constance V, Bensadoun André, Fong Loren G, Young Stephen G   Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1 Human molecular genetics, 2012; 21(13): 2961-72.
Chang Sandy Y, Hudon-Miller Sarah E, Yang Shao H, Jung Hea-Jin, Lee John M, Farber Emily, Subramanian Thangaiah, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Young Stephen G, Fong Loren G   Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 Journal of lipid research, 2012; 53(6): 1176-82.
Young Stephen G, Jung Hea-Jin, Coffinier Catherine, Fong Loren G   Understanding the roles of nuclear A- and B-type lamins in brain development The Journal of biological chemistry, 2012; 287(20): 16103-10.
Young Stephen G, Fong Loren G   Lowering plasma cholesterol by raising LDL receptors--revisited The New England journal of medicine, 2012; 366(12): 1154-5.
Davies Brandon S J, Beigneux Anne P, Fong Loren G, Young Stephen G   New wrinkles in lipoprotein lipase biology Current opinion in lipidology, 2012; 23(1): 35-42.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G   Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice Arteriosclerosis, thrombosis, and vascular biology, 2012; 32(2): 230-5.
Jung Hea-Jin, Coffinier Catherine, Choe Youngshik, Beigneux Anne P, Davies Brandon S J, Yang Shao H, Barnes Richard H, Hong Janet, Sun Tao, Pleasure Samuel J, Young Stephen G, Fong Loren G   Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(7): E423-31.
Smith Stuart, Witkowski Andrzej, Moghul Ayesha, Yoshinaga Yuko, Nefedov Michael, de Jong Pieter, Feng Dejiang, Fong Loren, Tu Yiping, Hu Yan, Young Stephen G, Pham Thomas, Cheung Carling, Katzman Shana M, Brand Martin D, Quinlan Casey L, Fens Marcel, Kuypers Frans, Misquitta Stephanie, Griffey Stephen M, Tran Son, Gharib Afshin, Knudsen Jens, Hannibal-Bach Hans Kristian, Wang Grace, Larkin Sandra, Thweatt Jennifer, Pasta Saloni   Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium PloS one, 2012; 7(10): e47196.
Yang Shao H, Chang Sandy Y, Tu Yiping, Lawson Gregory W, Bergo Martin O, Fong Loren G, Young Stephen G   Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases Journal of lipid research, 2012; 53(1): 77-86.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G   Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons Molecular biology of the cell, 2011; 22(23): 4683-93.
Yang Shao H, Jung Hea-Jin, Coffinier Catherine, Fong Loren G, Young Stephen G   Are B-type lamins essential in all mammalian cells? Nucleus (Austin, Tex.), 2011; 2(6): 562-9.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P   GPIHBP1, an endothelial cell transporter for lipoprotein lipase Journal of lipid research, 2011; 52(11): 1869-84.
Patwari Parth, Emilsson Valur, Schadt Eric E, Chutkow William A, Lee Samuel, Marsili Alessandro, Zhang Yongzhao, Dobrin Radu, Cohen David E, Larsen P Reed, Zavacki Ann Marie, Fong Loren G, Young Stephen G, Lee Richard T   The arrestin domain-containing 3 protein regulates body mass and energy expenditure Cell metabolism, 2011; 14(5): 671-83.
Yang Shao H, Chang Sandy Y, Yin Liya, Tu Yiping, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Fong Loren G, Young Stephen G   An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair Human molecular genetics, 2011; 20(18): 3537-44.
Beigneux Anne P, Davies Brandon S J, Tat Shelly, Chen Jenny, Gin Peter, Voss Constance V, Weinstein Michael M, Bensadoun André, Pullinger Clive R, Fong Loren G, Young Stephen G   Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase The Journal of biological chemistry, 2011; 286(22): 19735-43.
Im Seung-Soon, Yousef Leyla, Blaschitz Christoph, Liu Janet Z, Edwards Robert A, Young Stephen G, Raffatellu Manuela, Osborne Timothy F   Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a Cell metabolism, 2011; 13(5): 540-9.
Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G   Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(19): 7980-4.
Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter   Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists Molecular and cellular biology, 2011; 31(9): 1885-93.
Verstraeten Valerie L R M, Peckham Lana A, Olive Michelle, Capell Brian C, Collins Francis S, Nabel Elizabeth G, Young Stephen G, Fong Loren G, Lammerding Jan   Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(12): 4997-5002.
Feig Jonathan E, Parathath Sajesh, Rong James X, Mick Stephanie L, Vengrenyuk Yuliya, Grauer Lisa, Young Stephen G, Fisher Edward A   Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques Circulation, 2011; 123(9): 989-98.
Yang Shao H, Chang Sandy Y, Ren Shuxun, Wang Yibin, Andres Douglas A, Spielmann H Peter, Fong Loren G, Young Stephen G   Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin Human molecular genetics, 2011; 20(3): 436-44.
Gin Peter, Beigneux Anne P, Voss Constance, Davies Brandon S J, Beckstead Jennifer A, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G   Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells Arteriosclerosis, thrombosis, and vascular biology, 2011; 31(1): 176-82.
Vergnes Laurent, Chin Robert, Young Stephen G, Reue Karen   Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance The Journal of biological chemistry, 2011; 286(1): 380-90.
Davies Brandon Sj, Coffinier Catherine, Yang Shao H, Barnes Richard H, Jung Hea-Jin, Young Stephen G, Fong Loren G   Investigating the purpose of prelamin A processing Nucleus (Austin, Tex.), 2011; 2(1): 4-9.
Bishop Joseph R, Passos-Bueno Maria Rita, Fong Loren, Stanford Kristin I, Gonzales Jon C, Yeh Erika, Young Stephen G, Bensadoun Andre, Witztum Joseph L, Esko Jeffrey D, Moulton Karen S   Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans PloS one, 2010; 5(11): e13919.
Shu Xiao, Nelbach Lisa, Weinstein Michael M, Burgess Braydon L, Beckstead Jennifer A, Young Stephen G, Ryan Robert O, Forte Trudy M   Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(12): 2504-9.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G   Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning The Journal of biological chemistry, 2010; 285(50): 39239-48.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G   Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(11): 2106-13.
Hernandez Lidia, Roux Kyle J, Wong Esther Sook Miin, Mounkes Leslie C, Mutalif Rafidah, Navasankari Raju, Rai Bina, Cool Simon, Jeong Jae-Wook, Wang Honghe, Lee Hyun-Shik, Kozlov Serguei, Grunert Martin, Keeble Thomas, Jones C Michael, Meta Margarita D, Young Stephen G, Daar Ira O, Burke Brian, Perantoni Alan O, Stewart Colin L   Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria Developmental cell, 2010; 19(3): 413-25.
Coffinier Catherine, Fong Loren G, Young Stephen G   LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins Nucleus (Austin, Tex.), 2010; 1(5): 407-11.
Davies Brandon S J, Barnes Richard H, Tu Yiping, Ren Shuxun, Andres Douglas A, Spielmann H Peter, Lammerding Jan, Wang Yibin, Young Stephen G, Fong Loren G   An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria Human molecular genetics, 2010; 19(13): 2682-94.
Coffinier Catherine, Jung Hea-Jin, Li Ziwei, Nobumori Chika, Yun Ui Jeong, Farber Emily A, Davies Brandon S, Weinstein Michael M, Yang Shao H, Lammerding Jan, Farahani Javad N, Bentolila Laurent A, Fong Loren G, Young Stephen G   Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice The Journal of biological chemistry, 2010; 285(27): 20818-26.
Davies Brandon S J, Beigneux Anne P, Barnes Richard H, Tu Yiping, Gin Peter, Weinstein Michael M, Nobumori Chika, Nyrén Rakel, Goldberg Ira, Olivecrona Gunilla, Bensadoun André, Young Stephen G, Fong Loren G   GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries Cell metabolism, 2010; 12(1): 42-52.
Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG.   Abnormal patterns of lipoprotein lipase release into the plasma in GPIHPB1-deficient mice , J. Biol. Chem. , 2010; 12: 34511–34518.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.   HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells, Proc. Natl. Acad. Sci. USA, 2010; 104: 13432-13437.
Olivecrona Gunilla, Ehrenborg Ewa, Semb Henrik, Makoveichuk Elena, Lindberg Anna, Hayden Michael R, Gin Peter, Davies Brandon S J, Weinstein Michael M, Fong Loren G, Beigneux Anne P, Young Stephen G, Olivecrona Thomas, Hernell Olle   Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia Journal of lipid research, 2010; 51(6): 1535-45.
Franssen Remco, Young Stephen G, Peelman Frank, Hertecant Jozef, Sierts Jeroen A, Schimmel Alinda W M, Bensadoun André, Kastelein John J P, Fong Loren G, Dallinga-Thie Geesje M, Beigneux Anne P   Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects Circulation. Cardiovascular genetics, 2010; 3(2): 169-78.
Lee Roger, Chang Sandy Y, Trinh Hung, Tu Yiping, White Andrew C, Davies Brandon S J, Bergo Martin O, Fong Loren G, Lowry William E, Young Stephen G   Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes Human molecular genetics, 2010; 19(8): 1603-17.
Liu Meng, Sjogren Anna-Karin M, Karlsson Christin, Ibrahim Mohamed X, Andersson Karin M E, Olofsson Frida J, Wahlstrom Annika M, Dalin Martin, Yu Huiming, Chen Zhenggang, Yang Shao H, Young Stephen G, Bergo Martin O   Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(14): 6471-6.
Coffinier Catherine, Chang Sandy Y, Nobumori Chika, Tu Yiping, Farber Emily A, Toth Julia I, Fong Loren G, Young Stephen G   Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(11): 5076-81.
Yang Shao H, Chang Sandy Y, Andres Douglas A, Spielmann H Peter, Young Stephen G, Fong Loren G   Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria Journal of lipid research, 2010; 51(2): 400-5.
Weinstein Michael M, Yin Liya, Tu Yiping, Wang Xuping, Wu Xiaohui, Castellani Lawrence W, Walzem Rosemary L, Lusis Aldons J, Fong Loren G, Beigneux Anne P, Young Stephen G   Chylomicronemia elicits atherosclerosis in mice--brief report Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(1): 20-3.
Chan Lai N, Hart Courtenay, Guo Lea, Nyberg Tamara, Davies Brandon S J, Fong Loren G, Young Stephen G, Agnew Brian J, Tamanoi Fuyuhiko   A novel approach to tag and identify geranylgeranylated proteins Electrophoresis, 2009; 30(20): 3598-606.
Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Fong Loren G, Young Stephen G   Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase The Journal of biological chemistry, 2009; 284(44): 30240-7.
Berry Christopher J, Miller Jordan D, McGroary KellyAnn, Thedens Daniel R, Young Stephen G, Heistad Donald D, Weiss Robert M   Biventricular adaptation to volume overload in mice with aortic regurgitation Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2009; 11(17): 27.
Im Seung-Soon, Hammond Linda E, Yousef Leyla, Nugas-Selby Cherryl, Shin Dong-Ju, Seo Young-Kyo, Fong Loren G, Young Stephen G, Osborne Timothy F   Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2 Molecular and cellular biology, 2009; 29(17): 4864-72.
Fong Loren G, Vickers Timothy A, Farber Emily A, Choi Christine, Yun Ui Jeong, Hu Yan, Yang Shao H, Coffinier Catherine, Lee Roger, Yin Liya, Davies Brandon S J, Andres Douglas A, Spielmann H Peter, Bennett C Frank, Young Stephen G   Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides Human molecular genetics, 2009; 18(13): 2462-71.
Worman Howard J, Fong Loren G, Muchir Antoine, Young Stephen G   Laminopathies and the long strange trip from basic cell biology to therapy The Journal of clinical investigation, 2009; 119(7): 1825-36.
Park Kye Won, Waki Hironori, Kim Woo-Kyun, Davies Brandon S J, Young Stephen G, Parhami Farhad, Tontonoz Peter   The small molecule phenamil induces osteoblast differentiation and mineralization Molecular and cellular biology, 2009; 29(14): 3905-14.
Lee R, Chang SY, Trinh H, White AC, Bergo MO, Fong LG, Lowry WE, and Young SG.   Genetic Analysis of the Importance of the Protein Prenyltransferases in Skin Keratinocytes, Human Molecular Gen, 2009; (19): 1603-1617.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG.   Chylomicronemia with a Mutant GPIHBP1 (Q115P) that Cannot Bind Lipoprotein Lipase. , Arterioscler Thromb Vasc Biol, 2009; (29): 956-962.
Yang Shao H, Bergo Martin O, Farber Emily, Qiao Xin, Fong Loren G, Young Stephen G   Caution! Analyze transcripts from conditional knockout alleles Transgenic research, 2009; 18(3): 483-9.
Beigneux Anne P, Weinstein Michael M, Davies Brandon S J, Gin Peter, Bensadoun André, Fong Loren G, Young Stephen G   GPIHBP1 and lipolysis: an update Current opinion in lipidology, 2009; 20(3): 211-6.
Miller Jordan D, Weiss Robert M, Serrano Kristine M, Brooks Robert M, Berry Christopher J, Zimmerman Kathy, Young Stephen G, Heistad Donald D   Lowering plasma cholesterol levels halts progression of aortic valve disease in mice Circulation, 2009; 119(20): 2693-701.
Beigneux Anne P, Davies Brandon S J, Bensadoun André, Fong Loren G, Young Stephen G   GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins Journal of lipid research, 2009; 50 Suppl(20): S57-62.
Davies Brandon S J, Fong Loren G, Yang Shao H, Coffinier Catherine, Young Stephen G   The posttranslational processing of prelamin A and disease Annual review of genomics and human genetics, 2009; 10(20): 153-74.
Davies Brandon S J, Yang Shao H, Farber Emily, Lee Roger, Buck Suzanne B, Andres Douglas A, Spielmann H Peter, Agnew Brian J, Tamanoi Fuyuhiko, Fong Loren G, Young Stephen G   Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome Journal of lipid research, 2009; 50(1): 126-34.
Weinstein Michael M, Yin Liya, Beigneux Anne P, Davies Brandon S J, Gin Peter, Estrada Kristine, Melford Kristan, Bishop Joseph R, Esko Jeffrey D, Dallinga-Thie Geesje M, Fong Loren G, Bensadoun André, Young Stephen G   Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice The Journal of biological chemistry, 2008; 283(50): 34511-8.
Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G   The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma Molecular endocrinology (Baltimore, Md.), 2008; 22(11): 2496-504.
Peterson Andrew S, Fong Loren G, Young Stephen G   PCSK9 function and physiology Journal of lipid research, 2008; 49(7): 1595-9.
Yang SH, Andres DA, Spielmann HP, Young SG, and Fong LG.   Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated, J. Clin. Invest, 2008; 118: 3291-3300.
Gin P, Yin L, Davies BSJ, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, and Beigneux AP   The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons, J Biol. Chem, 2008; 283: 29554-29562.
Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Ryan Robert O, Fong Loren G, Young Stephen G   Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase Journal of lipid research, 2008; 49(6): 1312-21.
Coffinier Catherine, Hudon Sarah E, Lee Roger, Farber Emily A, Nobumori Chika, Miner Jeffrey H, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Fong Loren G, Young Stephen G   A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells The Journal of biological chemistry, 2008; 283(15): 9797-804.
Véniant Murielle M, Beigneux Anne P, Bensadoun André, Fong Loren G, Young Stephen G   Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models Current drug targets, 2008; 9(3): 174-89.
Gin Peter, Beigneux Anne P, Davies Brandon, Young Madeline F, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G   Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution Biochimica et biophysica acta, 2007; 1771(12): 1464-8.
Young Stephen G, Davies Brandon S J, Fong Loren G, Gin Peter, Weinstein Michael M, Bensadoun André, Beigneux Anne P   GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons Current opinion in lipidology, 2007; 18(4): 389-96.
Coffinier Catherine, Hudon Sarah E, Farber Emily A, Chang Sandy Y, Hrycyna Christine A, Young Stephen G, Fong Loren G   HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(33): 13432-7.
Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG.   Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons, Cell Metabolism, 2007; 5: 279–291.