Stephen Young, M.D.

Login to edit your profile page

Titles

Distinguished Professor, Medicine

Professor, Human Genetics

Member, Biochemistry, Biophysics & Structural Biology GPB Home Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Faculty, Cardiology

Contact Information

Email
sgyoung@mednet.ucla.edu
Phone
Fax Number: (310) 206-0865
Office Phone Number: (310) 825-4934
Address

Department Address:

UCLA Med-Cardio
650 Charles E. Young Drive South
A2-237 CHS Bldg.
Los Angeles, CA 90095
UNITED STATES

Office Address:

GONDA 4506A
695 Charles E. Young Drive South
GONDA 4506A
Los Angeles, CA 90095
UNITED STATES

Website
https://younglab.dgsom.ucla.edu

Biography

Stephen Young grew up in Kansas and obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University-St. Louis, he did internal medicine training at UCSF and cardiology training at UCSD. He then embarked on a career in basic science. He did postdoctoral research training in lipid metabolism at UCSD with Dr. Joseph Witztum and then worked at a UCSF-affiliated research institute for 17 years. Along the way, he became an expert in using genetically modified mice to investigate the gene function in health and disease. Currently, his laboratory studies an endothelial cell protein required for plasma triglyceride metabolism and diseases of the nuclear envelope. His laboratory has a strong track record in developing the careers of young scientists. Dr. Young has received multiple awards and is a member of the National Academy of Sciences.

Publications

A selected list of publications:

Kristensen Kristian K, Leth-Espensen Katrine Zinck, Young Stephen G, Ploug Michael   ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain Journal of lipid research, 2020; 58(5): 110612.
Belling Jason N, Heidenreich Liv K, Tian Zhenhua, Mendoza Alexandra M, Chiou Tzu-Ting, Gong Yao, Chen Natalie Y, Young Thomas D, Wattanatorn Natcha, Park Jae Hyeon, Scarabelli Leonardo, Chiang Naihao, Takahashi Jack, Young Stephen G, Stieg Adam Z, De Oliveira Satiro, Huang Tony Jun, Weiss Paul S, Jonas Steven J   Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells Proceedings of the National Academy of Sciences of the United States of America, 2020; 61(5): 589-590.
He Cuiwen, Jiang Haibo, Song Wenxin, Riezman Howard, Tontonoz Peter, Weston Thomas A, Guagliardo Paul, Kim Paul H, Jung Rachel, Heizer Patrick, Fong Loren G, Young Stephen G   Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins Proceedings of the National Academy of Sciences of the United States of America, 2020; 117(19): 10476-10483.
Heizer Patrick J, Yang Ye, Tu Yiping, Kim Paul H, Chen Natalie Y, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Morales Jazmin E, Li Robert L, Jackson Nicholas, Reue Karen, Young Stephen G, Fong Loren G   Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores Journal of lipid research, 2020; 61(3): 413-421.
Meng Xia, Zeng Wenwen, Young Stephen G, Fong Loren G   GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells Journal of lipid research, 2020; 61(5): 591.
Young Stephen G   Images in Lipid Research Journal of lipid research, 2020; 61(5): 589-590.
Jiang Haibo, He Cuiwen, Fong Loren G, Young Stephen G   The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes Journal of lipid research, 2020; 63(8): 3935-3955.
Kristensen Kristian K, Leth-Espensen Katrine Zinck, Mertens Haydyn D T, Birrane Gabriel, Meiyappan Muthuraman, Olivecrona Gunilla, Jørgensen Thomas J D, Young Stephen G, Ploug Michael   Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism Proceedings of the National Academy of Sciences of the United States of America, 2020; 117(8): 4337-4346.
Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP.   GPIHBP1 autoantibody syndrome during interferon β1a treatment Journal of Clinical Lipidology, 2019; 13(1): 62-69.
Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K.   Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis The Journal of Clinical Investigation, 2019; 129(1): 281-295.
Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong SG, Young SG.   Lipoprotein lipase is active as a monomer Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(13): 6319-6328.
Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M.   Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(5): 1723-1732.
Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.   A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(26): E6020-E6029.
Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG.   An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner Journal of Lipid Research, 2018; 13(1): 62-69.
Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.   Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells Cell, 2018; 175(2): 514-529.e20.
Kim PH, Luu J, Heizer , Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG.   Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome Science Translational Medicine, 2018; 10(460): 10100-10105.
Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG.   Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(40): 10100-10105.
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.   Macrophages release plasma membrane-derived particles rich in accessible cholesterol Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(36): E8499-E8508.
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.   NanoSIMS analysis of intravascular lipolysis and lipid movement across capillaries and into cardiomyocytes Cell Metabolism, 2018; 27(5): 1055-1066.e3.
He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H.   NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes Biochemical and Biophysical Research Communications, 2018; 504(4): 899-902.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.   Autoantibodies against GPIHBP1 as a cause of hypertriglyceridemia The New England Journal of Medicine, 2017; 376(17): 1647-1658.
Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TL, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP   GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia Journal of clinical lipidology, 2017; 11(4): 964-971.
He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H.   High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(8): 2000-2005.
Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries Journal of Lipid Research, 2017; 58(1): 216-225.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP.   Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL Journal of Lipid Research, 2017; 58(1): 208-215.
Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TL, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG.   Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding Journal of Lipid Research, 2017; 58(7): 1453-1461.
Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P.   RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs The Journal of Clinical Investigation, 2017; 127(3): 987-1004.
Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP.   An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1 Journal of Lipid Research, 2016; 57(10): 1889-1898.
Dijk W, Beigneux AP, Larsson M, Bensadoun A, Young SG, Kersten S.   Angiopoietin-like 4 (ANGPTL4) promotes intracellular degradation of lipoprotein lipase in adipocytes Journal of Lipid Research, 2016; 10(4): .
Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M.   GPIHBP1 and plasma triglyceride metabolism Trends in Endocrinology and Metabolism: TEM, 2016; .
Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG.   LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A Nucleus (Austin, Tex.), 2016; 7(5): 512-521.
Razafsky D, Ward C, Potter C, Zhu W, Xue Y, Kefalov VJ, Fong LG, Young SG, Hodzic D.   Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development Molecular Biology of the Cell, 2016; 27(12): 1928-37.
Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett C F, Young SG, Fong LG.   Modulation of LMNA splicing as a strategy to treat prelamin A diseases The Journal of Clinical Investigation, 2016; 126(4): 1592-602.
Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K.   SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression Journal of Lipid Research, 2016; 57(3): 410-21.
Mysling S, Kristensen KKølby, Larsson M, Beigneux AP, GÃ¥rdsvoll H, Fong LG, Bensadouen A, Jørgensen TJd, Young SG, Ploug M.   The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain eLife, 2016; 5(2): e12095.
Mysling S, Kristensen KK, Larsson M, Kovrov O, Bensadouen A, Jørgensen TJ, Olivecrona G, Young SG, Ploug M.   The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding eLife, 2016; 5(1): 216-225.
Beigneux AP, Fong LG, Bensadoun A, Davies BSJ, Oberer M, GÃ¥rdsvoll H, Ploug M, Young SG.   GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding Circulation Research, 2015; 116(4): 624-32.
Rong X, Wang B, Dunham MM, Hedde Per N, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P.   Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion eLife, 2015; 4(1665): .
Yang SH, Procaccia S, Jung H, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG.   Mice that express farnesylated versions of prelamin A in neurons develop achalasia Human Molecular Genetics, 2015; 24(10): 2826-40.
Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG.   An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin Molecular and Cellular Biology, 2014; 34(24): 4534-44.
Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CRM, Fong LG, Young SG.   High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis Journal of Lipid Research, 2014; 55(10): 2156-66.
Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, GÃ¥rdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP.   Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain The Journal of Biological Chemistry, 2014; 289(28): 19491-9.
Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG.   New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome Human Molecular Genetics, 2014; 23(6): 1506-15.
Young SG, Jung HJ, Lee JM, Fong LG,   Nuclear lamins and neurobiology Molecular and Cellular Biology, 2014; 34(15): 2776-85.
Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG.   Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2 Molecular Biology of the Cell, 2014; 25(10): 1666-75.
Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CRM, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG.   The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries Cell Metabolism, 2014; 19(5): 849-60.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.   Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell Metabolism, 2013; 17(3): 423-35.
Young SG, Zechner R.   Biochemistry and pathophysiology of intravascular and intracellular lipolysis Genes & Development, 2013; 27(5): 459-84.
Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG.   Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(21): E1923-32.
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P.   IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor Molecular and Cellular Biology, 2013; 33(8): 1503-14.
Jung HJ, Lee JM, Yang SH, Young SG, Fong LG.   Nuclear lamins in the brain - new insights into function and regulation Molecular Neurobiology, 2013; 47(1): 290-301.
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D.   SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion eLife, 2013; 2(4): e00444.
Young SG, Yang SH, Davies BSJ, Jung HJ, Fong LG.   Targeting protein prenylation in progeria Science Translational Medicine, 2013; 5(171): 171ps3.
Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BSJ, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG.   Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1 Human Molecular Genetics, 2012; 21(13): 2961-72.
Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann PH, Hrycyna CA, Young SG, Fong LG.   Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 Journal of Lipid Research, 2012; 53(6): 1176-82.
Young SG, Fong LG.   Lowering plasma cholesterol by raising LDL receptors--revisited The New England Journal of Medicine, 2012; 366(12): 1154-5.
Weinstein MM, Goulbourne CN, Davies BSJ, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG.   Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32(2): 230-5.
Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BSJ, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG.   Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(7): E423-31.
Yang SH, Chang SY, Tu Y, Lawson GW, Bergo MO, Fong LG, Young SG.   Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases Journal of Lipid Research, 2012; 53(1): 77-86.
Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG.   Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin Human Molecular Genetics, 2011; 20(3): 436-44.
Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG.   An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair Human Molecular Genetics, 2011; 20(18): 3537-44.
Beigneux AP, Davies BSJ, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG.   Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase The Journal of Biological Chemistry, 2011; 286(22): 19735-43.
Gin P, Beigneux AP, Voss C, Davies BSJ, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG.   Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology, 2011; 31(1): 176-82.
Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG.   Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons Molecular Biology of the Cell, 2011; 22(23): 4683-93.
Young SG, Davies BSJ, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP.   GPIHBP1, an endothelial cell transporter for lipoprotein lipase Journal of Lipid Research, 2011; 52(11): 1869-84.
Davies BSJ, Coffinier C, Yang SH, Barnes RH, Jung HJ, Young SG, Fong LG.   Investigating the purpose of prelamin A processing Nucleus (Austin, Tex.), 2011; 2(1): 4-9.
Voss CV, Davies BSJ, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG.   Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(19): 7980-4.
Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG.   Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(11): 5076-81.
Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG.   Abnormal patterns of lipoprotein lipase release into the plasma in GPIHPB1-deficient mice , The Journal of Biological Chemistry, 2010; 12: 34511–34518.
Davies BSJ, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG.   An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria Human Molecular Genetics, 2010; 19(13): 2682-94.
Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG.   Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria Journal of Lipid Research, 2010; 51(2): 400-5.
Weinstein MM, Tu Y, Beigneux AP, Davies BSJ, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG.   Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(11): 2106-13.
Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG.   Chylomicronemia elicits atherosclerosis in mice--brief report Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(1): 20-3.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG.   Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice The Journal of Biological Chemistry, 2010; 285(27): 20818-26.
Davies BSJ, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG.   GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries Cell Metabolism, 2010; 12(1): 42-52.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.   HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells, Proceedings of the National Academy of Sciences of the United States of America, 2010; 104: 13432-13437.
Coffinier C, Fong LG, Young SG.   LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins Nucleus (Austin, Tex.), 2010; 1(5): 407-11.
Olafsen T, Young SG, Davies BSJ, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG.   Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning The Journal of Biological Chemistry, 2010; 285(50): 39239-48.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BSJ, Andres DA, Spielmann HP, Bennett CF, Young SG.   Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides Human Molecular Genetics, 2009; 18(13): 2462-71.
Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG.   Caution! Analyze transcripts from conditional knockout alleles Transgenic Research, 2009; 18(3): 483-9.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG.   Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. , Arteriosclerosis, Thrombosis, and Vascular Biology, 2009; (29): 956-962.
Beigneux AP, Weinstein MM, Davies BSJ, Gin P, Bensadoun A, Fong LG, Young SG.   GPIHBP1 and lipolysis: an update Current Opinion in Lipidology, 2009; 20(3): 211-6.
Beigneux AP, Davies BSJ, Bensadoun A, Fong LG, Young SG.   GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins Journal of Lipid Research, 2009; 50 Suppl(20): S57-62.
Beigneux AP, Gin P, Davies BSJ, Weinstein MM, Bensadoun A, Fong LG, Young SG.   Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase The Journal of Biological Chemistry, 2009; 284(44): 30240-7.
Davies BSJ, Yang SH, Farber E, Lee R Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG.   Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome Journal of Lipid Research, 2009; 50(1): 126-34.
Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF.   Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2 Molecular and Cellular Biology, 2009; 29(17): 4864-72.
Davies BSJ, Fong LG, Yang SH, Coffinier C, Young SG.   The posttranslational processing of prelamin A and disease Annual Review of Genomics and Human Genetics, 2009; 10(20): 153-74.
Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann P, Hrycyna CA, Fong LG, Young SG.   A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells The Journal of Biological Chemistry, 2008; 283(15): 9797-804.
Weinstein MM, Yin L, Beigneux AP, Davies BSJ, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG.   Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice The Journal of Biological Chemistry, 2008; 283(50): 34511-8.
Beigneux AP, Gin P, Davies BSJ, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG.   Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase Journal of Lipid Research, 2008; 49(6): 1312-21.
Gin P, Yin L, Davies BSJ, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, and Beigneux AP.   The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons, Journal of Biological Chemistry, 2008; 283: 29554-29562.
Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG.   Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons, Cell Metabolism, 2007; 5: 279–291.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.   HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(33): 13432-7.