Rhonda R. Voskuhl, M.D.

Voskuhl Rhonda R, Wang HeJing, Wu T C Jackson, Sicotte Nancy L, Nakamura Kunio, Kurth Florian, Itoh Noriko, Bardens Jenny, Bernard Jacqueline T, Corboy John R, Cross Anne H, Dhib-Jalbut Suhayl, Ford Corey C, Frohman Elliot M, Giesser Barbara, Jacobs Dina, Kasper Lloyd H, Lynch Sharon, Parry Gareth, Racke Michael K, Reder Anthony T, Rose John, Wingerchuk Dean M, MacKenzie-Graham Allan J, Arnold Douglas L, Tseng Chi Hong, Elashoff Robert   Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial The Lancet. Neurology, 2016; 15(1): 35-46.

Voskuhl Rhonda   Preclinical studies of sex differences: a clinical perspective Biology of sex differences, 2016; 7: 7.

Kim Roy Y, Hoffman Alexandria S, Itoh Noriko, Ao Yan, Spence Rory, Sofroniew Michael V, Voskuhl Rhonda R   Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis Journal of neuroimmunology, 2014; 274(1-2): 53-61.

Kurth Florian, Luders Eileen, Sicotte Nancy L, Gaser Christian, Giesser Barbara S, Swerdloff Ronald S, Montag Michael J, Voskuhl Rhonda R, Mackenzie-Graham Allan   Neuroprotective effects of testosterone treatment in men with multiple sclerosis NeuroImage. Clinical, 2014; 4(7): 454-60.

Du Sienmi, Itoh Noriko, Askarinam Sahar, Hill Haley, Arnold Arthur P, Voskuhl Rhonda R   XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(7): 2806-11.

Spence Rory D, Wisdom Amy J, Cao Yuan, Hill Haley M, Mongerson Chandler R L, Stapornkul Briana, Itoh Noriko, Sofroniew Michael V, Voskuhl Rhonda R   Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(26): 10924-33.

Wisdom Amy J, Cao Yuan, Itoh Noriko, Spence Rory D, Voskuhl Rhonda R   Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model Journal of neuroscience research, 2013; 91(7): 901-8.

Voskuhl Rhonda R   Assisted reproduction technology in multiple sclerosis: giving birth to a new avenue of research in hormones and autoimmunity Annals of neurology, 2012; 72(5): 631-2.

MacKenzie-Graham Allan, Rinek Gilda A, Avedisian Andrea, Gold Stefan M, Frew Andrew J, Aguilar Cynthia, Lin David R, Umeda Elizabeth, Voskuhl Rhonda R, Alger Jeffry R   Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging NeuroImage, 2012; 60(1): 95-104.

Gold Stefan M, Sasidhar Manda V, Lagishetty Venu, Spence Rory D, Umeda Elizabeth, Ziehn Marina O, Krieger Thorsten, Schulz Karl-Heinz, Heesen Christoph, Hewison Martin, Voskuhl Rhonda R   Dynamic Development of Glucocorticoid Resistance during Autoimmune Neuroinflammation The Journal of clinical endocrinology and metabolism, 2012; 97(8): E1402-10.

Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, O'Dell Thomas J, Voskuhl Rhonda R   Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease Laboratory investigation; a journal of technical methods and pathology, 2012; 92(8): 1234-45.

MacKenzie-Graham Allan J, Rinek Gilda A, Avedisian Andrea, Morales Laurie B, Umeda Elizabeth, Boulat Benoit, Jacobs Russell E, Toga Arthur W, Voskuhl Rhonda R   Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis Journal of neuroscience research, 2012; 90(7): 1310-23.

Spence Rory D, Voskuhl Rhonda R   Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration Frontiers in neuroendocrinology, 2012; 33(1): 105-15.

Daumer Martin, Weinshenker Brian G, Voskuhl Rhonda   Pregnancy: a "modifiable" risk factor in MS? Neurology, 2012; 78(12): 846-8.

Voskuhl Rhonda R, Gold Stefan M   Sex-related factors in multiple sclerosis susceptibility and progression Nature reviews. Neurology, 2012; 8(5): 255-63.

Sasidhar Manda V, Itoh Noriko, Gold Stefan M, Lawson Gregory W, Voskuhl Rhonda R   The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY Annals of the rheumatic diseases, 2012; 71(8): 1418-22.

Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, Umeda Elizabeth A, O'Dell Thomas J, Voskuhl Rhonda R   Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(36): 12312-24.

Mangiardi Mario, Crawford Daniel K, Xia Xiaoyu, Du Sienmi, Simon-Freeman Rebecca, Voskuhl Rhonda R, Tiwari-Woodruff Seema K   An animal model of cortical and callosal pathology in multiple sclerosis Brain pathology (Zurich, Switzerland), 2011; 21(3): 263-78.

Du Sienmi, Sandoval Francisco, Trinh Pauline, Umeda Elizabeth, Voskuhl Rhonda   Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease European journal of immunology, 2011; 41(1): 140-50.

Spence Rory D, Hamby Mary E, Umeda Elizabeth, Itoh Noriko, Du Sienmi, Wisdom Amy J, Cao Yuan, Bondar Galyna, Lam Jeannie, Ao Yan, Sandoval Francisco, Suriany Silvie, Sofroniew Michael V, Voskuhl Rhonda R   Neuroprotection mediated through estrogen receptor-alpha in astrocytes Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(21): 8867-72.

Voskuhl Rhonda   Sex differences in autoimmune diseases Biology of sex differences, 2011; 2(1): 1.

Du Sienmi, Sandoval Francisco, Trinh Pauline, Voskuhl Rhonda R   Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis Journal of neuroimmunology, 2010; 219(1-2): 64-74.

Ziehn Marina O, Avedisian Andrea A, Tiwari-Woodruff Seema, Voskuhl Rhonda R   Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE Laboratory investigation; a journal of technical methods and pathology, 2010; 90(5): 774-86.

Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K   Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination Brain : a journal of neurology, 2010; 133(10): 2999-3016.

Voskuhl Rhonda, Wu T C Jackson   Do estroprogestinic hormones protect against chemotherapy-induced amenorrhea in multiple sclerosis? Nature clinical practice. Neurology, 2009; 5(1): 18-9.

Gold Stefan M, Voskuhl Rhonda R   Estrogen and testosterone therapies in multiple sclerosis Progress in brain research, 2009; 175(37): 239-51.

Gold Stefan M, Sasidhar Manda V, Morales Laurie B, Du Sienmi, Sicotte Nancy L, Tiwari-Woodruff Seema K, Voskuhl Rhonda R   Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha) Laboratory investigation; a journal of technical methods and pathology, 2009; 89(10): 1076-83.

Gold Stefan M, Voskuhl Rhonda R   Estrogen treatment in multiple sclerosis Journal of the neurological sciences, 2009; 286(1-2): 99-103.

Tiwari-Woodruff Seema, Voskuhl Rhonda R   Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice Journal of the neurological sciences, 2009; 286(1-2): 81-5.

MacKenzie-Graham Allan, Tiwari-Woodruff Seema K, Sharma Gaurav, Aguilar Cynthia, Vo Kieumai T, Strickland Lauren V, Morales Laurie, Fubara Boma, Martin Melanie, Jacobs Russell E, Johnson G Allan, Toga Arthur W, Voskuhl Rhonda R   Purkinje cell loss in experimental autoimmune encephalomyelitis NeuroImage, 2009; 48(4): 637-51.

Voskuhl Rhonda R, Peterson R Scott, Song Bingbing, Ao Yan, Morales Laurie Beth J, Tiwari-Woodruff Seema, Sofroniew Michael V   Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(37): 11511-22.

Smith-Bouvier Deborah L, Divekar Anagha A, Sasidhar Manda, Du Sienmi, Tiwari-Woodruff Seema K, King Jennifer K, Arnold Arthur P, Singh Ram Raj, Voskuhl Rhonda R   A role for sex chromosome complement in the female bias in autoimmune disease The Journal of experimental medicine, 2008; 205(5): 1099-108.

Wu, J., Ohlsson, M., Warner, E.A., Loo, K.K., Hoang, T., Voskuhl, R.R., Havton, L.A.   Glial Reactions and Degeneration of Myelinated Processes in Spinal Cord Gray Matter in Chronic Experimental Autoimmune Encephalomyelitis, Neuroscience, 156(3): 586-96, 2008; .

Gold Stefan M, Chalifoux Sara, Giesser Barbara S, Voskuhl Rhonda R   Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone Journal of neuroinflammation, 2008; 5(1): 32.

Smith Deborah L, Dong Xin, Du Sienmi, Oh Myungshin, Singh Ram Raj, Voskuhl Rhonda R   A female preponderance for chemically induced lupus in SJL/J mice Clinical immunology (Orlando, Fla.), 2007; 122(1): 101-7.

Tiwari-Woodruff Seema, Morales Laurie Beth J, Lee Ruri, Voskuhl Rhonda R   Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(37): 14813-8.

Sicotte Nancy L, Giesser Barbara S, Tandon Vinita, Klutch Ricki, Steiner Barbara, Drain Ann E, Shattuck David W, Hull Laura, Wang He-Jing, Elashoff Robert M, Swerdloff Ronald S, Voskuhl Rhonda R   Testosterone treatment in multiple sclerosis: a pilot study Archives of neurology, 2007; 64(5): 683-8.

MacKenzie-Graham Allan, Tinsley Matthew R, Shah Kaanan P, Aguilar Cynthia, Strickland Lauren V, Boline Jyl, Martin Melanie, Morales Laurie, Shattuck David W, Jacobs Russell E, Voskuhl Rhonda R, Toga Arthur W   Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis NeuroImage, 2006; 32(3): 1016-23.

Gold Stefan M, Voskuhl Rhonda R   Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders Current opinion in investigational drugs (London, England : 2000), 2006; 7(7): 625-30.

Morales Laurie Beth J, Loo Kyi Kyi, Liu Hong-Biao, Peterson Cory, Tiwari-Woodruff Seema, Voskuhl Rhonda R   Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(25): 6823-33.

Palaszynski Karen M, Smith Deborah L, Kamrava Shana, Burgoyne Paul S, Arnold Arthur P, Voskuhl Rhonda R   A yin-yang effect between sex chromosome complement and sex hormones on the immune response Endocrinology, 2005; 146(8): 3280-5.

Liu Hongbiao, Ding Yi, Voskuhl Rhonda R   Method to detect functional estrogen receptor expression using estrogen receptor probing compound Journal of immunoassay & immunochemistry, 2005; 26(4): 295-301.

Palaszynski Karen M, Loo Kyi Kyi, Ashouri Judith F, Liu Hong-biao, Voskuhl Rhonda R   Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis Journal of neuroimmunology, 2004; 146(1-2): 144-52.

Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R   Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis Journal of neuroimmunology, 2004; 146(1-2): 209-15.

Palaszynski Karen M, Liu Hongbiao, Loo Kyi Kyi, Voskuhl Rhonda R   Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis Journal of neuroimmunology, 2004; 149(1-2): 84-9.

Sicotte Nancy L, Voskuhl Rhonda R, Bouvier Seth, Klutch Rochelle, Cohen Mark S, Mazziotta John C   Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla Investigative radiology, 2003; 38(7): 423-7.

Liu Hong-biao, Loo Kyi Kyi, Palaszynski Karen, Ashouri Judith, Lubahn Dennis B, Voskuhl Rhonda R   Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease Journal of immunology (Baltimore, Md. : 1950), 2003; 171(12): 6936-40.

Voskuhl Rhonda R, Pribyl Thomas M, Kampf Kathy, Handley Vance, Liu Hong-biao, Feng JiMing, Campagnoni Celia W, Soldan Samantha S, Messing Albee, Campagnoni Anthony T   Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice Journal of neuroimmunology, 2003; 139(1-2): 44-50.

Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R   Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol Journal of immunology (Baltimore, Md. : 1950), 2003; 171(11): 6267-74.

Voskuhl Rhonda R   Gender issues and multiple sclerosis Current neurology and neuroscience reports, 2002; 2(3): 277-86.

Sicotte Nancy L, Liva Stephanie M, Klutch Rochelle, Pfeiffer Paul, Bouvier Seth, Odesa Sylvia, Wu T C Jackson, Voskuhl Rhonda R   Treatment of multiple sclerosis with the pregnancy hormone estriol Annals of neurology, 2002; 52(4): 421-8.

Voskuhl, R. R. Palaszynski, K.   Sex hormones and experimental autoimmune encephalomyelitis:Implications for multiple sclerosis, The Neuroscientist, 2001; 7(3): 258-270.

Liva, S.M. Voskuhl, R.R.   Testosterone acts directly on CD4+ T-lymphocytes to increase IL10 production, Journal of Immunology, 2001; 167: 2060-2067.