Ernest Noble, M.D., Ph.D.

Titles

Emeritus Member, Brain Research Institute

Professor Emeritus, Psychiatry and Biobehavioral Sciences

Semel Institute for Neuroscience and Human Behavior


Awards and Honors:

Stanford University Medical Center

Stanford University Medical Center

Centre de Neurochimie

Contact Information

Email
epnoble@ucla.edu
Phone
Work Phone Number: 310-825-1891
Address

Mailing Address:

Alcohol Research Center
UCLA Dept. of Psychiatry & Biobehavioral Sciences
760 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES

Biography

Dr. Ernest P. Noble (Professor of Psychiatry & Biobehavioral Sciences, Emeritus) is a biochemist and clinical psychiatrist. Dr. Noble came to UCLA in 1981 with a distinguished academic and service career. After many years as a faculty member at Stanford University and the University of California at Irvine, Dr. Noble became the Director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in Washington, DC (1976-78). After coming to UCLA in 1981, he was appointed the Pike Professor of Alcohol Studies and Director of the UCLA Alcohol Research Center. Dr. Noble was also former Vice-President of the National Council on Alcoholism, and former President of the International Commission for the Prevention of Alcoholism and Drug Dependency. He received a B.S. degree in Chemistry from the University of California at Berkeley, a Ph.D. in biochemistry from Oregon State University, completed a postdoctoral fellowship and an M.D.degree at Case Western Reserve University, followed by medical internship and psychiatric residency training at Stanford University. He performed research as a Fulbright Scholar at the Sorbonne in Paris, France, as a Guggenheim Fellow at the Centre de Neurochimie in Strasbourg, France, and as a Senior Fulbright Scholar at the Max-Planck Institute for Psychiatry in Munich, Germany. Dr. Noble has over 400 scientific and medical publications and is a member of numerous editorial boards and scientific and professional societies, and has received many honors for his achievements.

Publications

Goenjian Armen K, Bailey Julia N, Walling David P, Steinberg Alan M, Schmidt Devon, Dandekar Uma, Noble Ernest P   Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms Journal of affective disorders, 2012; 196(2-3): .
Bailey Julia N, Goenjian Armen K, Noble Ernest P, Walling David P, Ritchie Terry, Goenjian Haig A   PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake Psychiatry research, 2010; 178(3): 507-10.
London Edythe D, Berman Steven M, Mohammadian Parvenah, Ritchie Terrie, Mandelkern Mark A, Susselman Mary K W, Schlagenhauf Florian, Noble Ernest P   Effect of the TaqIA polymorphism on ethanol response in the brain Psychiatry research, 2009; 174(3): 163-70.
Berman Steven M, Noble Ernest P, Mohammadian Parvaneh, Ritchie Terry, Mandelkern Mark A, London Edythe D   Laterality of cortical response to ethanol is moderated by TaqIA A1 allele Synapse (New York, N.Y.), 2009; 63(9): 817-21.
Antolin Tim, Berman Steven M, Conner Bradley T, Ozkaragoz Tulin Z, Sheen Courtney L, Ritchie Terry L, Noble Ernest P   D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics Psychiatry research, 2009; 166(2-3): 91-101.
Barnard Neal D, Noble Ernest P, Ritchie Terry, Cohen Joshua, Jenkins David J A, Turner-McGrievy Gabrielle, Gloede Lise, Green Amber A, Ferdowsian Hope   D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes Nutrition (Burbank, Los Angeles County, Calif.), 2009; 25(1): 58-65.
Goenjian Armen K, Noble Ernest P, Walling David P, Goenjian Haig A, Karayan Ida S, Ritchie Terry, Bailey Julia N   Heritabilities of symptoms of posttraumatic stress disorder, anxiety, and depression in earthquake exposed Armenian families Psychiatric genetics, 2008; 18(6): 261-6.
Connor Jason P, Young Ross McD, Saunders John B, Lawford Bruce R, Ho Robert, Ritchie Terry L, Noble Ernest P   The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity Psychiatry research, 2008; 160(1): 94-105.
Connor Jason P, Young Ross McD, Lawford Bruce R, Saunders John B, Ritchie Terry L, Noble Ernest P   Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism Addictive behaviors, 2007; 32(2): 310-9.
Barnes Mark, Lawford Bruce R, Burton Simon C, Heslop Karen R, Noble Ernest P, Hausdorf Karrin, Young Ross McD   Smoking and schizophrenia: is symptom profile related to smoking and which antipsychotic medication is of benefit in reducing cigarette use? The Australian and New Zealand journal of psychiatry, 2007; 40(6-7): 575-80.
Lawford Bruce R, Young Ross, Noble Ernest P, Kann Burnett, Ritchie Terry   The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder European psychiatry : the journal of the Association of European Psychiatrists, 2006; 21(3): 180-5.
Berman Steven M, Noble Ernest P, Antolin Tim, Sheen Courtney, Conner Bradley T, Ritchie Terry   P300 development during adolescence: effects of DRD2 genotype Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006; 117(3): 649-59.
Conner Bradley T, Noble Ernest P, Berman Steven M, Ozkaragoz Tulin, Ritchie Terry, Antolin Tim, Sheen Courtney   DRD2 genotypes and substance use in adolescent children of alcoholics Drug and alcohol dependence, 2005; 79(3): 379-87.
Young Ross McD, Lawford Bruce R, Barnes Mark, Burton Simon C, Ritchie Terry, Ward Warren K, Noble Ernest P   Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele The British journal of psychiatry : the journal of mental science, 2004; 185(3): 147-51.
Young Ross McD, Lawford Bruce R, Feeney Gerald F X, Ritchie Terry, Noble Ernest P   Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAA receptor beta3 subunit genes Psychiatry research, 2004; 127(3): 171-83.
Lawford Bruce R, McD Young Ross, Noble Ernest P, Kann Burnett, Arnold Leanne, Rowell John, Ritchie Terry L   D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003; 13(5): 313-20.
Berman Steven M, Ozkaragoz Tulin, Noble Ernest P, Antolin Tim, Sheen Courtney, Siddarth Prabha, Conner Bradley T, Ritchie Terry   Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics Alcohol (Fayetteville, N.Y.), 2003; 30(3): 201-10.
Ritchie Terry, Noble Ernest P   Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics Neurochemical research, 2003; 28(1): 73-82.
Noble Ernest P   D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2003; 116B(1): 103-25.
Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ   Allelic association of the D2 dopamine receptor gene with receptor binding characteristics in alcoholism, Arch Gen Psychiatry , 1991; 48: 648-654.
Blum K, Noble EP, Sheridan PJ, Finley O, Montgomery A, Ritchie T, Ozkaragoz T, Fitch RJ, Sadlack F, Sheffield D, Dahlmann T, Halbardier S, Nogami H   Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism, Alcohol, 1991; 8: 409-416.
Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB   Allelic association of human dopamine D2 receptor gene in alcoholism, JAMA, 1990; 263: 2055-2060.