Elyse J. Singer, M.D.

Thames April D, Briones Marisa S, Magpantay Larry I, Martinez-Maza Otoniel, Singer Elyse J, Hinkin Charles H, Morgello Susan, Gelman Benjamin B, Moore David J, Heizerling Keith, Levine Andrew J   The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients AIDS (London, England), 2015; 29(12): 1483-91.

Anderson Albert M, Harezlak Jaroslaw, Bharti Ajay, Mi Deming, Taylor Michael J, Daar Eric S, Schifitto Giovanni, Zhong Jianhui, Alger Jeffry R, Brown Mark S, Singer Elyse J, Campbell Thomas B, McMahon Deborah D, Buchthal Steven, Cohen Ronald, Yiannoutsos Constantin, Letendre Scott L, Navia Bradford A, Navia Bradford A   Plasma and Cerebrospinal Fluid Biomarkers Predict Cerebral Injury in HIV-Infected Individuals on Stable Combination Antiretroviral Therapy Journal of acquired immune deficiency syndromes (1999), 2015; 69(1): 29-35.

Kim Joseph Y, Singer Elyse J, Bonelli Laura, Klausner Jeffrey D   A case of primary HIV type 1 and cytomegalovirus coinfection presenting with widespread clinical disease Journal of the International Association of Providers of AIDS Care, 2015; 13(3): 196-9.

Fogel Gary B, Lamers Susanna L, Levine Andrew J, Valdes-Sueiras Miguel, McGrath Michael S, Shapshak Paul, Singer Elyse J   Factors related to HIV-associated neurocognitive impairment differ with age Journal of neurovirology, 2015; 21(1): 56-65.

Thames April D, Castellon Steven A, Singer Elyse J, Nagarajan Rajakumar, Sarma Manoj K, Smith Jason, Thaler Nicholas S, Truong Jonathan Hien, Schonfeld Daniel, Thomas M Albert, Hinkin Charles H   Neuroimaging abnormalities, neurocognitive function, and fatigue in patients with hepatitis C Neurology® neuroimmunology & neuroinflammation, 2015; 2(1): e59.

Lou Jerry J, Mirsadraei Leili, Sanchez Desiree E, Wilson Ryan W, Shabihkhani Maryam, Lucey Gregory M, Wei Bowen, Singer Elyse J, Mareninov Sergey, Yong William H   A review of room temperature storage of biospecimen tissue and nucleic acids for anatomic pathology laboratories and biorepositories Clinical biochemistry, 2014; 47(4-5): 267-73.

Shabihkhani Maryam, Lucey Gregory M, Wei Bowen, Mareninov Sergey, Lou Jerry J, Vinters Harry V, Singer Elyse J, Cloughesy Timothy F, Yong William H   The procurement, storage, and quality assurance of frozen blood and tissue biospecimens in pathology, biorepository, and biobank settings Clinical biochemistry, 2014; 47(4-5): 258-66.

Panos Stella E, Del Re A C, Thames April D, Arentsen Timothy J, Patel Sapna M, Castellon Steven A, Singer Elyse J, Hinkin Charles H   The impact of neurobehavioral features on medication adherence in HIV: evidence from longitudinal models AIDS care, 2014; 26(1): 79-86.

Levine Andrew J, Horvath Steve, Miller Eric N, Singer Elyse J, Shapshak Paul, Baldwin Gayle C, Martínez-Maza Otoniel, Witt Mallory D, Langfelder Peter   Transcriptome analysis of HIV-infected peripheral blood monocytes: gene transcripts and networks associated with neurocognitive functioning Journal of neuroimmunology, 2013; 265(1-2): 96-105.

Gongvatana Assawin, Harezlak Jaroslaw, Buchthal Steven, Daar Eric, Schifitto Giovanni, Campbell Thomas, Taylor Michael, Singer Elyse, Algers Jeffrey, Zhong Jianhui, Brown Mark, McMahon Deborah, So Yuen T, Mi Deming, Heaton Robert, Robertson Kevin, Yiannoutsos Constantin, Cohen Ronald A, Navia Bradford, Navia Bradford   Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy Journal of neurovirology, 2013; 19(3): 209-18.

Hua Xue, Boyle Christina P, Harezlak Jaroslaw, Tate David F, Yiannoutsos Constantin T, Cohen Ron, Schifitto Giovanni, Gongvatana Assawin, Zhong Jianhui, Zhu Tong, Taylor Michael J, Campbell Thomas B, Daar Eric S, Alger Jeffry R, Singer Elyse, Buchthal Steve, Toga Arthur W, Navia Bradford, Thompson Paul M, Thompson Paul M   Disrupted cerebral metabolite levels and lower nadir CD4Â + counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatment NeuroImage. Clinical, 2013; 3(2): 132-42.

Singer Elyse J, Valdes-Sueiras Miguel, Commins Deborah L, Yong William, Carlson Margrit   HIV stroke risk: evidence and implications Therapeutic advances in chronic disease, 2013; 4(2): 61-70.

Levine Andrew J, Miller Jeremy A, Shapshak Paul, Gelman Benjamin, Singer Elyse J, Hinkin Charles H, Commins Deborah, Morgello Susan, Grant Igor, Horvath Steve   Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease BMC medical genomics, 2013; 6(2): 4.

Lamers Susanna L, Fogel Gary B, Singer Elyse J, Salemi Marco, Nolan David J, Huysentruyt Leanne C, McGrath Michael S   HIV-1 Nef in macrophage-mediated disease pathogenesis International reviews of immunology, 2012; 31(6): 432-50.

Gelman Benjamin B, Lisinicchia Joshua G, Morgello Susan, Masliah Eliezer, Commins Deborah, Achim Cristian L, Fox Howard S, Kolson Dennis L, Grant Igor, Singer Elyse, Yiannoutsos Constantin T, Sherman Seth, Gensler Gary, Moore David J, Chen Tiansheng, Soukup Vicki M   Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort Journal of acquired immune deficiency syndromes (1999), 2012; .

Soontornniyomkij Virawudh, Moore David J, Gouaux Ben, Soontornniyomkij Benchawanna, Tatro Erick T, Umlauf Anya, Masliah Eliezer, Levine Andrew J, Singer Elyse J, Vinters Harry V, Gelman Benjamin B, Morgello Susan, Cherner Mariana, Grant Igor, Achim Cristian L   Cerebral ?-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ?4 carriers AIDS (London, England), 2012; 26(18): 2327-35.

Levine Andrew J, Service Susan, Miller Eric N, Reynolds Sandra M, Singer Elyse J, Shapshak Paul, Martin Eileen M, Sacktor Ned, Becker James T, Jacobson Lisa P, Thompson Paul, Freimer Nelson   Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012; 159B(6): 669-83.

Kamat Anupa, Lyons Jennifer L, Misra Vikas, Uno Hajime, Morgello Susan, Singer Elyse J, Gabuzda Dana   Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection Journal of acquired immune deficiency syndromes (1999), 2012; 60(3): 234-43.

Levine Andrew J, Sinsheimer Janet S, Bilder Robert, Shapshak Paul, Singer Elyse J   Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults Journal of clinical and experimental neuropsychology, 2012; 34(1): 78-91.

Dye Richelin V, Miller Karen J, Singer Elyse J, Levine Andrew J   Hormone replacement therapy and risk for neurodegenerative diseases International journal of Alzheimer's disease, 2012; 2012(4): 258454.

Robinson-Papp Jessica, Gelman Benjamin B, Grant Igor, Singer Elyse, Gensler Gary, Morgello Susan, Morgello Susan   Substance abuse increases the risk of neuropathy in an HIV-infected cohort Muscle & nerve, 2012; 45(4): 471-6.

Gelman Benjamin B, Chen Tiansheng, Lisinicchia Joshua G, Soukup Vicki M, Carmical J Russ, Starkey Jonathan M, Masliah Eliezer, Commins Deborah L, Brandt Dianne, Grant Igor, Singer Elyse J, Levine Andrew J, Miller Jeremy, Winkler Jessica M, Fox Howard S, Luxon Bruce A, Morgello Susan, Morgello Susan   The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment PloS one, 2012; 7(9): e46178.

Sowmya Gopichandran, Shamini Gunasagaran, Anita Sathyanarayanan, Sakharkar Meena, Mathura Venkat, Rodriguez Hector, Levine Andrew J, Singer Elyse, Commins Deborah, Somboonwit Charurut, Sinnott John T, Sidhu Harcharan S, Rajaseger Ganapathy, Pushparaj Peter Natesan, Kangueane Pandajarasamme, Shapshak Paul   HIV-1 envelope accessible surface and polarity: clade, blood, and brain Bioinformation, 2011; 6(2): 48-56.

Lyons Jennifer L, Uno Hajime, Ancuta Petronela, Kamat Anupa, Moore David J, Singer Elyse J, Morgello Susan, Gabuzda Dana   Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection Journal of acquired immune deficiency syndromes (1999), 2011; 57(5): 371-9.

Tate David F, Sampat Mehul, Harezlak Jaroslaw, Fiecas Mark, Hogan Joseph, Dewey Jeffrey, McCaffrey Daniel, Branson Daniel, Russell Troy, Conley Jared, Taylor Michael, Schifitto Giovanni, Schifitto Giavoni, Zhong J, Daar Eric S, Alger Jeffrey, Brown Mark, Singer Elyse, Campbell T, McMahon D, Tso Y, Matesan Janetta, Letendre Scott, Paulose S, Gaugh Michelle, Tripoli C, Yiannoutsos Constantine, Bigler Erin D, Cohen Ronald A, Guttmann Charles R G, Navia Bradford, Navia Bradford   Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies Journal of neurovirology, 2011; 17(4): 368-79.

Harezlak Jarek, Buchthal Steven, Taylor Michael, Schifitto Giovanni, Zhong Jianhui, Daar Eric, Alger Jeffrey, Singer Elyse, Campbell Thomas, Yiannoutsos Constantin, Cohen Ronald, Navia Bradford, Navia Bradford   Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment AIDS (London, England), 2011; 25(5): 625-33.

Thames April D, Becker Brian W, Marcotte Thomas D, Hines Lindsay J, Foley Jessica M, Ramezani Amir, Singer Elyse J, Castellon Steven A, Heaton Robert K, Hinkin Charles H   Depression, cognition, and self-appraisal of functional abilities in HIV: an examination of subjective appraisal versus objective performance The Clinical neuropsychologist, 2011; 25(2): 224-43.

Thames April D, Kim Michelle S, Becker Brian W, Foley Jessica M, Hines Lindsay J, Singer Elyse J, Heaton Robert K, Castellon Steven A, Hinkin Charles H   Medication and finance management among HIV-infected adults: the impact of age and cognition Journal of clinical and experimental neuropsychology, 2011; 33(2): 200-9.

Shapshak Paul, Kangueane Pandjassarame, Fujimura Robert K, Commins Deborah, Chiappelli Francesco, Singer Elyse, Levine Andrew J, Minagar Alireza, Novembre Francis J, Somboonwit Charurut, Nath Avindra, Sinnott John T   Editorial neuroAIDS review AIDS (London, England), 2011; 25(2): 123-41.

Shapshak Paul, Somboonwit Charurut, Sinnott John, Commins Deborah, Singer Elyse, Levine Andrew   Gene-chromosome locations of neuropsychiatric diseases Bioinformation, 2011; 7(7): 366-8.

Shapshak Paul, Duncan Robert, Kangueane Pandajarasamme, Somboonwit Charurut, Sinnott John, Commins Deborah, Singer Elyse, Levine Andrew   HIV associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis) Bioinformation, 2011; 6(5): 183-6.

Cohen Ronald A, Harezlak Jaroslaw, Gongvatana Assawin, Buchthal Steven, Schifitto Giovanni, Clark Uraina, Paul Robert, Taylor Michael, Thompson Paul, Tate David, Alger Jeffery, Brown Mark, Zhong Jianhui, Campbell Thomas, Singer Elyse, Daar Eric, McMahon Deborah, Tso Yuen, Yiannoutsos Constantin T, Navia Bradford, Navia Bradford   Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes Journal of neurovirology, 2010; 16(6): 435-44.

Cohen Ronald A, Harezlak Jaroslaw, Schifitto Giovanni, Hana George, Clark Uraina, Gongvatana Assawin, Paul Robert, Taylor Michael, Thompson Paul, Alger Jeffery, Brown Mark, Zhong Jianhui, Campbell Thomas, Singer Elyse, Daar Eric, McMahon Deborah, Tso Yuen, Yiannoutsos Constantin T, Navia Bradford   Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era Journal of neurovirology, 2010; 16(1): 25-32.

Zhao Yu, Navia Bradford A, Marra Christina M, Singer Elyse J, Chang Linda, Berger Joseph, Ellis Ronald J, Kolson Dennis L, Simpson David, Miller Eric N, Lipton Stuart A, Evans Scott R, Schifitto Giovanni, Schifitto Giovanni   Memantine for AIDS dementia complex: open-label report of ACTG 301 HIV clinical trials, 2010; 11(1): 59-67.

Singer Elyse J, Valdes-Sueiras Miguel, Commins Deborah, Levine Andrew   Neurologic presentations of AIDS Neurologic clinics, 2010; 28(1): 253-75.

Levine Andrew J, Singer Elyse J, Sinsheimer Janet S, Hinkin Charles H, Papp Jeanette, Dandekar Sugandha, Giovanelli Allison, Shapshak Paul   CCL3 genotype and current depression increase risk of HIV-associated dementia Neurobehavioral HIV medicine, 2009; 1(1): 1-7.

Kumar Adarsh M, Fernandez J B, Singer Elyse J, Commins Deborah, Waldrop-Valverde Drenna, Ownby Raymond L, Kumar Mahendra   Human immunodeficiency virus type 1 in the central nervous system leads to decreased dopamine in different regions of postmortem human brains Journal of neurovirology, 2009; 15(3): 257-74.

Micheletti Robert G, Fishbein Gregory A, Fishbein Michael C, Singer Elyse J, Weiss Robert E, Jeffries Robin A, Currier Judith S   Coronary atherosclerotic lesions in human immunodeficiency virus-infected patients: a histopathologic study Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 2009; 18(1): 28-36.

Giunta Brian, Hou Houyan, Zhu Yuyan, Rrapo Elona, Tian Jun, Takashi Mori, Commins Deborah, Singer Elyse, He Johnny, Fernandez Francisco, Tan Jun   HIV-1 Tat contributes to Alzheimer's disease-like pathology in PSAPP mice International journal of clinical and experimental pathology, 2009; 2(5): 433-43.

Shapshak Paul, Somboonwit Charurut, Drumright Lydia N, Frost Simon D W, Commins Deborah, Tellinghuisen Timothy L, Scott William K, Duncan Robert, McCoy Clyde, Page J Bryan, Giunta Brian, Fernandez Francisco, Singer Elyse, Levine Andrew, Minagar Alireza, Oluwadara Oluwadayo, Kotila Taiwo, Chiappelli Francesco, Sinnott John T   Molecular and contextual markers of hepatitis C virus and drug abuse Molecular diagnosis & therapy, 2009; 13(3): 153-79.

Levine Andrew J, Singer Elyse J, Shapshak Paul   The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders AIDS and behavior, 2009; 13(1): 118-32.

Levine Andrew J, Hinkin Charles H, Ando Kazuhiro, Santangelo Gianni, Martinez Mariana, Valdes-Sueiras Miguel, Saxton Ernestina H, Mathisen Glen, Commins Deborah L, Moe Ardis, Farthing Charles, Singer Elyse J   An exploratory study of long-term neurocognitive outcomes following recovery from opportunistic brain infections in HIV+ adults Journal of clinical and experimental neuropsychology, 2008; 30(7): 836-43.

Fishbein Gregory A, Micheletti Robert G, Currier Judith S, Singer Elyse, Fishbein Michael C   Atherosclerotic oxalosis in coronary arteries Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 2008; 17(2): 117-23.

Micheletti Robert G, Fishbein Gregory A, Currier Judith S, Singer Elyse J, Fishbein Michael C   Calcification of the internal elastic lamina of coronary arteries Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008; 21(8): 1019-28.

Fiala Milan, Singer Elyse J, Commins Deborah, Mirzapoiazova Tamara, Verin Alexander, Espinosa Araceli, Ugen Kenneth, Bernas Michael, Witte Marlys, Weinand Martin, Lossinsky Albert S   HIV-1 Antigens in Neurons of Cocaine-Abusing Patients The open virology journal, 2008; 2(1): 24-31.

Ancuta Petronela, Kamat Anupa, Kunstman Kevin J, Kim Eun-Young, Autissier Patrick, Wurcel Alysse, Zaman Tauheed, Stone David, Mefford Megan, Morgello Susan, Singer Elyse J, Wolinsky Steven M, Gabuzda Dana   Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients PloS one, 2008; 3(6): e2516.

Chiappelli Francesco, Shapshak Paul, Commins Deborah, Singer Elyse, Minagar Alireza, Oluwadara Oluwadayo, Prolo Paolo, Pellionisz Andras J   Molecular epigenetics, chromatin, and NeuroAIDS/HIV: immunopathological implications Bioinformation, 2008; 3(1): 47-52.

Shapshak Paul, Chiappelli Francesco, Commins Deborah, Singer Elyse, Levine Andrew J, Somboonwit Charurut, Minagar Alireza, Pellionisz Andras J   Molecular epigenetics, chromatin, and NeuroAIDS/HIV: translational implications Bioinformation, 2008; 3(1): 53-7.

Minagar Alireza, Commins Deborah, Alexander J Steven, Hoque Romy, Chiappelli Francesco, Singer Elyse J, Nikbin Behrooz, Shapshak Paul   NeuroAIDS: characteristics and diagnosis of the neurological complications of AIDS Molecular diagnosis & therapy, 2008; 12(1): 25-43.

Hinkin Charles H, Castellon Steven A, Levine Andrew J, Barclay Terry R, Singer Elyse J   Neurocognition in individuals co-infected with HIV and hepatitis C Journal of addictive diseases, 2008; 27(2): 11-7.

Schifitto Giovanni, Navia Bradford A, Yiannoutsos Constantin T, Marra Christina M, Chang Linda, Ernst Thomas, Jarvik Jeffrey G, Miller Eric N, Singer Elyse J, Ellis Ronald J, Kolson Dennis L, Simpson David, Nath Avindra, Berger Joseph, Shriver Sharon L, Millar Linda L, Colquhoun Dodi, Lenkinski Robert, Gonzalez R Gilberto, Lipton Stuart A, Lipton Stuart A, Lipton Stuart A, Lipton Stuart A   Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study AIDS (London, England), 2007; 21(14): 1877-86.

Paul Robert H, Yiannoutsos Constantin T, Miller Eric N, Chang Linda, Marra Christina M, Schifitto Giovanni, Ernst Thomas, Singer Elyse, Richards Todd, Jarvik G Jeffrey, Price Richard, Meyerhoff Dieter J, Kolson Dennis, Ellis Ronald J, Gonzalez Gilberto, Lenkinski Robert E, Cohen Ronald A, Navia Bradford A   Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity The Journal of neuropsychiatry and clinical neurosciences, 2007; 19(3): 283-92.

Rohit Mona, Levine Andrew, Hinkin Charles, Abramyan Shogik, Saxton Ernestine, Valdes-Sueiras Miguel, Singer Elyse   Education correction using years in school or reading grade-level equivalent? Comparing the accuracy of two methods in diagnosing HIV-associated neurocognitive impairment Journal of the International Neuropsychological Society : JINS, 2007; 13(3): 462-70.

Schifitto Giovanni, Yiannoutsos Constantin T, Simpson David M, Marra Christina M, Singer Elyse J, Kolson Dennis L, Nath Avindra, Berger Joseph R, Navia Bradford, Navia Bradford   A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy Journal of neurovirology, 2006; 12(4): 328-31.

Fiala Milan, Eshleman Amy J, Cashman John, Lin Justin, Lossinsky Albert S, Suarez Vannina, Yang Wendy, Zhang Jun, Popik Waldemar, Singer Elyse, Chiappelli Francesco, Carro Eva, Weinand Martin, Witte Marlys, Arthos James   Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells Journal of neurovirology, 2005; 11(3): 281-91.

Woods Steven Paul, Rippeth Julie D, Frol Alan B, Levy Joel K, Ryan Elizabeth, Soukup Vicki M, Hinkin Charles H, Lazzaretto Deborah, Cherner Mariana, Marcotte Thomas D, Gelman Benjamin B, Morgello Susan, Singer Elyse J, Grant Igor, Heaton Robert K   Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV Journal of clinical and experimental neuropsychology, 2004; 26(6): 759-78.

Singer Elyse J   Patient page. A new clue in the mystery of neuro-AIDS Neurology, 2003; 60(12): E12-3.

Singer Elyse J, Aronow H Aaron, Lee Shing-Yi, Hinkin Charles H, Lazarus Tadd   Stability of human immunodeficiency virus type 1 RNA in cerebrospinal fluid determined with the AMPLICOR HIV-1 MONITOR test, version 1.5 (ultrasensitive) Journal of clinical microbiology, 2002; 40(10): 3863-4.