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Ellen M. Carpenter, Ph.D.
Professor, Psychiatry and Biobehavioral Sciences
PhoneFax Number: (310) 206-5050Lab Number: 310-267-2105Office Phone Number: 310-206-3404
AddressLaboratory Address: Laboratory635 Charles E Young Drive SouthNRB 304Los Angeles, CA 90095UNITED STATES Office Address: OfficeDepartment of Psychiatry and Biobehavioral SciencesMental Retardation Research Center635 Charles E Young Drive SouthNRB 303Mail Code 733222Los Angeles, CA 90095UNITED STATES
BiographyResearch Interest: Pattern formation during central nervous system development My laboratory is addressing the interactions that occur between members of the Hox gene family during embryonic development. Hox genes encode transcription factors that are expressed in broad anteroposterior domains in developing vertebrate embryos. Inactivation of different members of the Hox gene family suggests that these genes are active in embryonic patterning. We have defined the anatomical phenotypes for mice carrying mutations in several individual Hox genes and are currently breeding and analyzing mice carrying multiple mutations. Our studies have demonstrated that motor neuron position and projection is specifically affected by Hox gene mutations both individually and in combination. We are also examining downstream targets of Hox gene activity using microarray screening. We have identified a set of genes that are differentially expressed in the nervous system following mutation of a single Hox gene. Rt-PCR studies have demonstrated that some of these genes show additional changes in expression in double mutant animals, suggesting that several Hox genes may regulate the same downstream target genes. We are currently defining the promoter elements that may be responsible for these gene interactions.
Rebustini Ivan T, Hayashi Toru, Reynolds Andrew D, Dillard Melvin L, Carpenter Ellen M, Hoffman Matthew P miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis Development (Cambridge, England), 2012; 139(1): 191-202.
Hirose Megumi, Niewiadomski Pawel, Tse Gary, Chi Gloria C, Dong Hongmei, Lee Alice, Carpenter Ellen M, Waschek James A Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures Journal of neuroscience research, 2011; 89(9): 1363-74.
Khialeeva, E., Lane, T. F., and Carpenter, E. M. Disruption of reelin signaling alters mammary gland morphogenesis, Development, 2011; 138: 767-778.
Khialeeva Elvira, Lane Timothy F, Carpenter Ellen M Disruption of reelin signaling alters mammary gland morphogenesis Development (Cambridge, England), 2011; 138(4): 767-76.
Ghiani Cristina A, Mattan Natalia S, Nobuta Hiroko, Malvar Jemily S, Boles Julie, Ross Michael G, Waschek James A, Carpenter Ellen M, Fisher Robin S, de Vellis Jean Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat ASN neuro, 2011; 3(4): .
Hostikka, S. L., Gong, J., and Carpenter, E. M. Axial and appendicular skeletal transformation, ligament alterations, and motor neuron loss in Hoxc10 mutants, International Journal of Biological Sciences, 2009; 5: 397-410.
Misra, M., Shah, V., Carpenter, E., McCaffery, P., and Lance-Jones, C Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneurons subtype complement in the lumbosacral spinal cord, Developmental Biology, 2009; 330: 54-72.
Misra Mala, Shah Veeral, Carpenter Ellen, McCaffery Peter, Lance-Jones Cynthia Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord Developmental biology, 2009; 330(1): 54-72.
Hostikka Sirkka Liisa, Gong Jun, Carpenter Ellen M Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants International journal of biological sciences, 2009; 5(5): 397-410.
Malinin Theodore I, Carpenter Ellen M, Temple H Thomas Particulate bone allograft incorporation in regeneration of osseous defects; importance of particle sizes The open orthopaedics journal, 2007; 1(1): 19-24.
Carpenter Ellen M, Gendler El, Malinin Theodore I, Temple H Thomas Effect of hydrogen peroxide on osteoinduction by demineralized bone American journal of orthopedics (Belle Mead, N.J.), 2006; 35(12): 562-7.
Choe Andrea, Phun Huy Q, Tieu David D, Hu Yan Hong, Carpenter Ellen M Expression patterns of Hox10 paralogous genes during lumbar spinal cord development Gene expression patterns : GEP, 2006; 6(7): 730-7.
Choe, A., Phun, H. Q., Tieu, D. D., Hy, Y. H., and Carpenter, E. M. Expression patterns of Hox10 paralogous genes during lumbar spinal cord development Gene Expression Patterns, 2006; 7: 730-737.
Hedlund, E., Karsten, S. L., Kudo, L., Geschwind, D. H., and Carpenter, E. M. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development Journal of Neuroscience Research, 2004; 75: 307-319.
Hedlund Eva, Karsten Stanislav L, Kudo Lili, Geschwind Daniel H, Carpenter Ellen M Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development Journal of neuroscience research, 2004; 75(3): 307-19.
Lin Amy W, Carpenter Ellen M Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning Journal of neurobiology, 2003; 56(4): 328-37.
Carpenter, EM Hox genes and spinal cord development Developmental Neuroscience. , 2002; 24(1): 24-34.
Anderson Tonya R, Hedlund Eva, Carpenter Ellen M Differential Pax6 promoter activity and transcript expression during forebrain development Mechanisms of development, 2002; 114(1-2): 171-5.
Anderson, TR Hedlund, E Carpenter, EM Differential Pax6 promoter activity and transcript expression during forebrain development Mechanisms of Development. , 2002; 114(1-2): 171-5.
Carpenter Ellen M Hox genes and spinal cord development Developmental neuroscience, 2002; 24(1): 24-34.
Wahba, GM Hostikka, SL Carpenter, EM The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton Developmental Biology. , 2001; 231(1): 87-102.
de la Cruz, CC Der-Avakian, A Spyropoulos, DD Tieu, DD Carpenter, EM Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development Developmental Biology. , 1999; 216(2): 595-610.
Carpenter, EM Goddard, JM Davis, AP Nguyen, TP Capecchi, MR Targeted disruption of Hoxd-10 affects mouse hindlimb development Development (Cambridge, England) , 1997; 124(22): 4505-14.
Carpenter, EM Goddard, JM Chisaka, O Manley, NR Capecchi, MR Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain Development (Cambridge, England) , 1993; 118(4): 1063-75.