Charles L. Wilson, Ph.D.

Titles

Emeritus Member, Brain Research Institute

Professor Emeritus, Neurology

Contact Information

Email
clwilson@ucla.edu
Phone
Work Phone Number: 310-825-0576
Address

Mailing Address:

Department of Neurology
701 Westwood Plaza
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095
UNITED STATES

Office Address:

Office
710 Westwood Plaza
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095
UNITED STATES

Biography

Duties and Accomplishments Principal Investigator on multiple grants from NIH, NINDS, The Epilepsy Foundation, and American Society of Sleep Medicine. Human and animal research on the neurophysiology and neurochemistry of epilepsy, sleep, and the limbic system. He established the human microdialysis study program at UCLA Medical School in 1990, and continued human microdialysis research until 2015. His clinical duties included operating room targeting of depth electrode placements and operating room assisting in cortical grids placement in epilepsy patients from 1978 until 2010, as well as depth electrode stimulation and cortical grid functional mapping in epilepsy patients until 2006. Graduate teaching in Neuroscience, Neurobiology, Neuroengineering, Biomedical Engineering, UCLA Medical and Dental School Neuroanatomy and Neurobiology. Supervision and mentoring of graduate and postdoctoral students in Neurology and Neurobiology and Fellows in Neurology and Clinical Neurophysiology. Research Over 200 scientific journal publications, book chapters, reviews, and abstracts, over 30 invited talks at national and international scientific meetings, NIH study section reviewer for NINDS and NIBIB (2007) and reviewer for over 20 scientific journals between 1979 and 2015. Multiple publications on electrical stimulation of the human brain during clinical evaluation of patients with epilepsy, both for depth electrode and cortical grid functional mapping. Current membership in of the Society for Neuroscience and American Epilepsy Society, past member of the American Society of Sleep Medicine and American Clinical Neurophysiology Society. Committee service in UCLA Department of Neurology, UCLA Animal Research Committee, and American Epilepsy Society. Teaching Undergraduate Student Research Program, Neuroscience 199, 199Honors Graduate: PhD thesis advisor in Neurobiology, teaching classes in Neuroscience 275, Neurobiology M200A, Neuroengineering 212 and Biomedical Engineering M260. Medical School: Neuroanatomy M203, Dental School: Neurobiology 106, UCLA Department of Neurology Clinical Neurophysiology Lecture Series: “Cortical Grid and Depth Electrode Recording and Stimulation for Functional Brain Mapping” and “In Vivo Microdialysis Studies of Neurotransmitter Release in the Human Brain”.

Publications

Yetish Gandhi, Kaplan Hillard, Gurven Michael, Wood Brian, Pontzer Herman, Manger Paul R, Wilson Charles, McGregor Ronald, Siegel Jerome M   Natural sleep and its seasonal variations in three pre-industrial societies Current biology : CB, 2015; 25(21): 2862-8.
Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM.   Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction, Nat Commun, 2013; 4: 1547-56.
Ogren Jennifer A, Wilson Charles L, Bragin Anatol, Lin Jack J, Salamon Noriko, Dutton Rebecca A, Luders Eileen, Fields Tony A, Fried Itzhak, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J   Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus Annals of neurology, 2009; 66(6): 783-91.
Ogren Jennifer A, Bragin Anatol, Wilson Charles L, Hoftman Gil D, Lin Jack J, Dutton Rebecca A, Fields Tony A, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J   Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns Epilepsia, 2009; 50(6): 1361-70.
Staba Richard J, Frighetto Leonardo, Behnke Eric J, Mathern Gary W, Fields Tony, Bragin Anatol, Ogren Jennifer, Fried Itzhak, Wilson Charles L, Engel Jerome   Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients Epilepsia, 2007; 48(11): 2130-8.
Bragin Anatol, Claeys Pieter, Vonck Kristl, Van Roost Dirk, Wilson Charles, Boon Paul, Engel Jerome   Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy Epilepsia, 2007; 48(10): 1883-94.
Lopez-Rodriguez Faustino, Medina-Ceja Laura, Wilson Charles L, Jhung Donald, Morales-Villagran Alberto   Changes in extracellular glutamate levels in rat orbitofrontal cortex during sleep and wakefulness Archives of medical research, 2007; 38(1): 52-5.
Bragin Anatol, Wilson Charles L, Engel Jerome   Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus Epilepsia, 2007; 48 Suppl 5(1): 35-40.
Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L   Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study Sleep, 2006; 29(4): 455-61.
Schrader Lara M, Stern John M, Wilson Charles L, Fields Tony A, Salamon Noriko, Nuwer Marc R, Vespa Paul M, Fried Itzhak   Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006; 117(4): 781-8.
Schrader Lara M, Stern John M, Fields Tony A, Nuwer Marc R, Wilson Charles L   A lack of effect from transcranial magnetic stimulation (TMS) on the vagus nerve stimulator (VNS) Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2005; 116(10): 2501-4.
Bragin Anatol, Azizyan Avetis, Almajano Joyel, Wilson Charles L, Engel Jerome   Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats Epilepsia, 2005; 46(10): 1592-8.
Bragin Anatol, Wilson Charles L, Fields Tony, Fried Itzhak, Engel Jerome   Analysis of seizure onset on the basis of wideband EEG recordings Epilepsia, 2005; 46 Suppl 5(10): 59-63.
Bragin Anatol, Wilson Charles L, Almajano Joyel, Mody Istvan, Engel Jerome   High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis Epilepsia, 2004; 45(9): 1017-23.
Staba Richard J, Wilson Charles L, Bragin Anatol, Jhung Donald, Fried Itzhak, Engel Jerome   High-frequency oscillations recorded in human medial temporal lobe during sleep Annals of neurology, 2004; 56(1): 108-15.
Bragin Anatol, Karsten Stanislav L, Almajano Joyel, Wilson Charles L, Geschwind Daniel H, Engel Jerome   Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters Journal of neuroscience methods, 2004; 133(1-2): 49-55.
Koos Brian J, Kawasaki Yoshikazu, Hari Ashwinii, Bohorquez Fanor, Jan Calvin, Roostaeian Jason, Wilson Charles L, Kruger Lawrence   Electrical stimulation of the posteromedial thalamus modulates breathing in unanesthetized fetal sheep Journal of applied physiology (Bethesda, Md. : 1985), 2004; 96(1): 115-23.
Engel Jerome, Wilson Charles, Bragin Anatol   Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us? Epilepsia, 2003; 44 Suppl 12(9): 60-71.
Bragin Anatol, Wilson Charles L, Engel Jerome   Spatial stability over time of brain areas generating fast ripples in the epileptic rat Epilepsia, 2003; 44(9): 1233-7.
Cornford Eain M, Shamsa Kamran, Zeitzer Jamie M, Enriquez Cathleen M, Wilson Charles L, Behnke Eric J, Fried Itzhak, Engel Jerome   Regional analyses of CNS microdialysate glucose and lactate in seizure patients Epilepsia, 2002; 43(11): 1360-71.
Bragin Anatol, Wilson Charles L, Staba Richard J, Reddick Mark, Fried Itzhak, Engel Jerome   Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex Annals of neurology, 2002; 52(4): 407-15.
Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome   Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex Journal of neurophysiology, 2002; 88(4): 1743-52.
Bragin Anatol, Wilson Charles L, Engel Jerome   Increased afterdischarge threshold during kindling in epileptic rats Experimental brain research, 2002; 144(1): 30-7.
Mazarati Andrey, Bragin Anatol, Baldwin Roger, Shin Don, Wilson Charles, Sankar Raman, Naylor David, Engel Jerome, Wasterlain Claude G   Epileptogenesis after self-sustaining status epilepticus Epilepsia, 2002; 43 Suppl 5(5): 74-80.
Bragin Anatol, Mody Istvan, Wilson Charles L, Engel Jerome   Local generation of fast ripples in epileptic brain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(5): 2012-21.
Bragin Anatol, Wilson Charles L, Engel Jerome   Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents Epilepsia, 2002; 43 Suppl 5(5): 81-5.
Staba Richard J, Wilson Charles L, Fried Itzhak, Engel Jerome   Single neuron burst firing in the human hippocampus during sleep Hippocampus, 2002; 12(6): 724-34.