Natik Piri, Ph.D.


Professor, Ophthalmology

Member, Brain Research Institute

Neuroscience GPB Home Area

Stein Eye Institute

Contact Information

Lab Number: 310-206-7900
Office Phone Number: 310-825-9850

Work Address:

Los Angeles, CA 90095


Kwong J, Gu L, Nassiri N, Bekerman V, Kumar-Singh R, Rhee KD, Yang XJ, Hauswirth WW, Caprioli J, Piri N.   AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury, Gene Ther, 2015; 22: 138-145.
Kyung H, Kwong J, Bekerman V, Gu L, Yadegari D, Caprioli J, Piri N.   Celastrol supports survival of retinal ganglion cells injured by optic nerve crush, Brain Res, 2015; 1609: 21-30.
Piri N, Kwong JMK, Caprioli J.   Crystallins in retinal ganglion cell survival and regeneration, Mol. Neurobiol, 2013; 48: 819-828.
Munemasa Y, Chang CS, Kwong JM, Kyung H, Kitaoka Y, Caprioli J, Piri N.   The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic nerve injury, PLoS One, 2012; 7: e34810.
Kao L, Kurtz LM, Shao X, Papadopoulos MC, Liu L, Bok D, Nusinowitz S, Chen B, Stella SL, Andre M, Weinreb J, Luong SS, Piri N, Kwong JM, Newman D, Kurtz I.   Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5), J. Biol. Chem, 2011; 286: 32563-32574.
Munemasa Y, Kwong JK, Kim S, Ahn J, Caprioli J, Piri N.   Thioredoxins 1 and 2 protect retinal ganglion cells from pharmacologically induced oxidative stress, optic nerve transection and ocular hypertension, Adv. Exp. Med. Biol, 2010; 664: 355-363.
Kwong J, Caprioli J, Piri N.   RNA binding protein with multiple splicing: a new marker for retinal ganglion cells, Invest. Ophthalmol. Vis. Sci, 2010; 51: 1052-1058.
Munemasa Y, Kwong JK, Caprioli J, Piri N.   Alpha A and alpha B crystallins protect retinal ganglion cells from degeneration after optic nerve axotomy, Invest. Ophthalmol. Vis. Sci, 2009; 50: 3869-3875.
Munemasa Y, Kim SH, Ahn JH, Kwong JM, Caprioli J, Piri N.   Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma, Gene Ther, 2009; 16: 17-25.
Verardo M, Viczian A, Piri N, Akhmedov NB, Knox B, Farber B.   Regulatory sequences in the 3? untranslated region of the human cGMP-phosphodisterase beta-subunit gene, Invest. Ophthalmol. Vis. Sci, 2009; 50: 2591-2598.
Kim SH, Munemasa Y, Kwong JM, Ahn JH, Mareninov S, Gordon LK, Caprioli J, Piri N.   Activation of autophagy in retinal ganglion cells, J. Neurosci. Res, 2008; 86: 2943 - 2951.
Souied EH, Reid SN, Piri NI, Lerner LE, Nusinowitz S, Farber DB.   Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration, Exp. Eye Res, 2008; 87: 168-175.
Munemasa Y, Kim SH, Ahn JH, Kwong JM, Caprioli J, Piri N.   Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress, Invest. Ophthalmol. Vis. Sci, 2008; 49: 3535-3543.
Piri N, Song M, Kwong J.M.K., Caprioli J   Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration, Brain Res, 2007; 1141: 1-9.
Piri N, Kwong JMK, Song M, Caprioli J   Expression of hermes gene is restricted to the ganglion cells in the retina, Neurosci. Lett, 2006; 405: 40-45.
Piri N, Kwong JM, Song M, Elashoff D, Caprioli J.   Gene expression changes in the retina following optic nerve transection, Mol. Vision, 2006; 12: 1660-1673.
Piri N, Mendoza E, Akhmedov NB, Farber DB   The role of the 5' and 3' untranslated regions of the rod photoreceptor cGMP-phosphodiesterase in mRNA translation, Exp. Eye Res, 2006; 83: 841-848.
Piri N, Gao Y, Danciger M, Mendoza E, Fishman GA, Farber DB   A transition of G to C in the 5' untranslated region of the cone cGMP-phosphodiesterase gamma subunit and cone-rod dystrophy, Ophthalmology, 2005; 112: 159-166.
Piriev N, Yamashita CK, Shih J, Farber DB   Expression of functionally active cone photoreceptor cGMP-PDE alpha' subunit in chinese humster ovary, 293 human embryonic kidney and Y79 retinoblastoma cells, Mol. Vision, 2003; 9: 80-86.
Piri N, Yamashita CK, Shih J, Akhmedov NB, Farber DB   Regulation of rod photoreceptor cGMP-phosphodiesterase alpha and beta subunits expression: mRNA and protein levels, J. Biol. Chem, 2003; 278: 36999-37005.
Piriev N, Akhmedov NB, Chang B, Rapoport A, Hawes NL, Nishina PM, Nusiniwitz S, Heckenlively JH, Roderick TH, Kozak CA, Danciger M, Davisson MT, Farber DB   A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in rd7 mouse, Proc. Natl. Acad. Sci. USA, 2000; 97: 5551-5556.
Guillonneau X, Piriev N, Danciger M, Kozak CA, Cideciyan AV, Jacobson SG, Farber DB   A nonsense mutation in a novel gene is associated with retinitis pigmentosa in a family linked to the RP1 locus, Hum. Mol. Genet, 1999; 8: 1541-1546.
Gao YQ, Danciger M, Longmuir R, Piriev N, Zhao DY, Heckenlively JH, Fishman GA, Weleber RG, Jacobson SG, Stone EM, Farber DB   Exon screening of the gene encoding the alpha' subunit of cone cGMP-phosphodiesterase in patients with various forms of retinal degeneration, Invest. Ophthalmol. Vis. Sci, 1999; 40: 1818-1822.
Reid SNM, Akhmedov NB, Piriev N, Kozak CA, Dancinger M, Farber   The mouse X-linked juvenile retinoschisis cDNA: expression in photoreceptors, Gene, 1999; 227: 257-266.
Akhmedov NB, Piriev N, Perce-Kelling S, Acland GM, Aguirre GD, Farber DB   Canine cone transducin gamma gene and cone degeneration in cd dog, Invest. Ophthalmol. Vis. Sci, 1998; 39: 1775-1781.
Piriev N, Shih JM, Farber DB   Defective RNA splicing resulting from a mutation in the cyclic guanosine monophosphate-phosphodiesterase beta-subunit gene, Invest. Ophthalmol. Vis. Sci, 1998; 39: 463-470.
Akhmedov NB, Piriev N, Ray K, Acland GM, Aguirre GD, Farber DB   Structure and analysis of transducin beta3-subunit, a candidate for cone degeneration in the cd dog, Gene, 1997; 194: 47-56.
Gao YQ, Danciger M, Zhao DY, Blaney J, Piriev N, Shih J, Jacobson SG, Heckenlively JH, Farber DB   Screening of the PDE6B gene in patients with autosomal dominant retinitis pigmentosa, Exp. Eye Res, 1996; 62: 149-54.
Piriev N, Viczian AS, Ye J, Kerner, B, Korenberg, JR, Farber DB   Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24, Genomics, 1995; 28: 429-435.
Viczian AS, Piriev N, Farber DB   Isolation and sequence analysis of the human cone cGMP-phosphodiesterase alpha' subunit cDNA, Gene, 1995; 166: 205-211.
Piriev N, Khramtsov NV, Lipkin VM   Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells, Gene, 1994; 151: 297-301.
Piriev N, Yamashita C, Samuel G, Farber DB   Rod Photoreceptor cGMP-phosphodiesterase: Analysis of alpha and beta subunits expressed in human kidney cells, Proc. Natl. Acad. Sci. USA, 1993; 90: 9340-9344.