Kindling: A model of neural plasticity and behavioral consequences

Department of Psychology, and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada

In 1964 Graham Goddard employed a technique that involved the repeated administration of an electrical current to the amygdala while investigating the effects on memory. The technique has since become infamously known as "kindling" after it was first described in 1967 (Nature, v214) but coined in 1969 (J Comp Physiol Psych, v68). Since then the kindling phenomenon has been instrumental as a model of epileptogenesis: The anatomy, electrophysiology, and biochemical mechanisms underlying kindling have been thoroughly investigated. However, separate lines of kindling research have detailed the behavioral consequences of kindling that further model several of the pathologies comorbid in individuals with temporal lobe epilepsy, such as memory impairments, anxiety, fear, panic, and schizophrenia-like behavior. The kindling model is attractive not only because of the ability to examine seizure behavior in a progression manner but also because the behavioral consequences often develop in a similarly progressive manner. After almost 40 years of study, the kindling model remains a viable and influential tool for studying neural plasticity and the behavioral consequences.

Session VI -- Poster Session 1
Monday, 28 June 2004, 9:00 - 9:30 am

Ninth Annual Meeting of the International Society for the History of the Neurosciences (ISHN)

Montreal, Quebec, Canada