Symposium: "Opioids, the Janus Drugs, and the Relief of Pain" (2nd UCLA History of Pain Symposium: Los Angeles, California, 23-24 August 2002)
"Opioids, the Janus Drugs, and the Relief of Pain"
2nd UCLA History of Pain Symposium
An Official Satellite Symposium of the 10th World Congress on Pain
http://www.iasp-pain.org/02congopen.html
UCLA Faculty Center
Los Angeles, California, UCLA
23-24 August 2002
Program, CME information, Hotel accommodations, and HTML/PDF
registration forms (to accompany $75 registration fee):
http://www.library.ucla.edu/libraries/biomed/his2/painsymposium2002.html
Opium . . . The ancient Sumerians cultivated the opium poppy; the
great Islamic physician Avicenna died of an accidental,
self-administered overdose in 1037 C.E.; in the 17th century, Thomas
Sydenham wrote that no other pain reliever "is so universal and so
efficacious as opium." Opium was banned by imperial edict in China in
1799, but the trade had been so profitable to the East India Company
that the British fought two "Opium Wars" to force the Chinese again to
allow its importation. In the 20th century, beginning with the
International Congress of 1912, many of the world's nations placed
severe restrictions on the use of opium and its derivatives; these
sanctions failed to end narcotic smuggling and abuse but contributed to
the demonization of these drugs. By the 1950s, fears of addiction led
many physicians and nurses to limit opioid use despite its great value
in relieving the suffering of patients in severe and chronic pain.
Opioids . . . In the second half of the 20th century, researchers have
learned to describe the actions of opioid drugs in the human body,
discovered the endogenous substances and receptors that replicate their
effects, clarified the difference between addiction and dependence on
a drug for a medical need, and developed new formulations and methods
of delivery. In 1982 the World Health Organization launched a global
program to advocate the use of strong opioids for the management of
cancer pain, and their use in noncancer pain has improved the lives of
many. And yet, patients and clinicians are troubled by the enigma of
the opioids, the Janus drugs that show us two faces: the euphoria of
pain relief and the horror of addiction.
The target audience for this multidisciplinary symposium includes
physicians, nurses, pharmacists, and practitioners who work with
patients in pain, as well as all researchers interested in the history
of pain medicine. As a participant, you will hear distinguished
historians, scientists, physicians, and other scholars describe the
history of opioid use in patient care; the history of opioid research,
findings about the chemistry and pharmacology of both exogenous and
endogenous opioids, and the impact of this research on clinical
practice; and the new rationale of international health policy
regarding medical use of opioids. As a group, we will discuss the
relevance of this history to pain management today.
John C. Liebeskind History of Pain Collection
http://www.library.ucla.edu/libraries/biomed/his2/pain.html
The Setting: The UCLA Faculty Center is a modern facility on the
campus of this internationally recognized research university. As a
symposium participant, you will enjoy state-of-the-art audiovisual
capabilities and excellent catering as well as the delightful
California climate on the center's several patios. On Friday evening
you will be offered free bus transportation to the world-famous Getty
Center. After the conference adjourns at noon on Saturday, you may tour
the John C. Liebeskind History of Pain Collection, visit one of LA's
many museums or theme parks, or relax on the beach.
All symposium proceedings will be in English.
This symposium is presented by the UCLA John C. Liebeskind History of
Pain Collection and sponsored by the Office of CME, UCLA School of
Medicine, and the UCLA Neuropsychiatric Institute.
Accreditation: The Office of Continuing Medical Education, UCLA School
of Medicine, designates this continuing medical education activity for
up to 8 hours in Category I credit towards the AMA Physician's
Recognition Award. Each physician should claim only those hours of
credit that he/she actually spent in the educational activity.
Disclosure: The FDA has issued a concept paper which classifies
commercial support of scientific and educational programs as
promotional unless it can be affirmed that the program is "truly
independent" and free of commercial influence. In addition to
independence, the FDA requires that non-promotional, commercially
supported education be objective, balanced, and scientifically
rigorous. This policy further states that all potential conflicts of
interest of the CME staff and faculty be fully disclosed to the
program's participants. We at UCLA fully endorse the letter and spirit
of this concept. In compliance with this policy, the program will have
disclosed to it any potential conflict(s) of interest related to the
content of presentations made by all faculty participating in sponsored
or jointly sponsored programs by the UCLA School of Medicine.
UCLA Co-Chairs:
Marcia L. Meldrum, PhD
Lecturer, Department of History; Co-Director, John C. Liebeskind
History of Pain Collection
Joel T. Braslow, MD, PhD
Associate Professor in Residence, Psychiatry and Biobehavioral
Sciences, and History; Director, UCLA Neuroscience History Archives
Katharine E.S. Donahue, MLS
Head, History & Special Collections Division, Louise M. Darling
Biomedical Library; Co-Director, John C. Liebeskind History of Pain
Collection
PROGRAM
Friday, August 23, 2002
8 - 8:40 a.m.
Registration and continental breakfast
8:40 - 9 a.m.
Welcome to UCLA and Opening Remarks
Joel T. Braslow, MD, PhD
Associate Professor in Residence, Psychiatry and Biobehavioral
Sciences, UCLA
John D. Loeser, MD
IASP Past President; Professor, Neurological Surgery, University of
Washington
9 - 10 a.m.
Session I: Before the 20th Century
Walton G. Schalick III, MD, PhD
Assistant Professor, Pediatrics, Washington University/St. Louis
- on opium and pain relief in medieval Europe
Martha Stoddard Holmes, PhD
Assistant Professor, Literature, California State University/San Marcos
- on pain management and palliative care in the 19th century
10 - 10:30 a.m.
Discussion and coffee break
10:30 - 11:30 a.m.
Session II: The Opiate Molecule, 1900-2000
Caroline J. Acker, PhD
Assistant Professor, History, Carnegie Mellon University, Pittsburgh
- on the search for a nonaddicting analgesic
Kenner C. Rice, PhD
Drug Design and Synthesis Chief, Laboratory of Medicinal Chemistry,
National Institute of Diabetes and Digestive and Kidney Diseases
- on the laboratory synthesis of morphine
11:30 a.m. - 12 noon
Discussion
12 noon - 1:15 p.m.
Lunch with the speakers
1:15 - 2:15 p.m.
Session III: The Opiate Receptors, 1969-1990
Huda Akil, PhD
Gardner C. Quarton Professor of Neurosciences and Professor,
Psychiatry, University of Michigan
- on the phenomenon of stimulation-produced analgesia
Robert Kanigel
Professor, Science Writing and Humanistic Studies, Massachusetts
Institute of Technology
- on the isolation of the opiate receptors
2:15 - 2:45 p.m.
Discussion and coffee break
2:45 - 4:15 p.m.
Session IV: Clinical Research, 1950-2001
David Clark, PhD
Professor and Chair, Medical Sociology, University of Sheffield
- on the Brompton Cocktail
Christina Faull, MD
Medical Director, St. Mary's Hospice, Birmingham
- on palliative care research on opioid use
Michael Cousins, MD
Past IASP President; Professor and Head, Anaesthesia and
Pain Management, University of Sydney
- on pain management with spinal opioids
4:15 - 4:45 p.m.
Discussion
4:45 - 6 p.m.
Reception and buffet
6 p.m.
Buses leave for the Getty Center
9 p.m.
Buses return from the Getty Center
Saturday, August 24, 2002
8:30 - 9 a.m.
Continental breakfast
9 - 10:30 a.m.
Session V: A New Paradigm and a New Policy, 1982-2001
Marcia L. Meldrum, PhD
Co-Director, John C. Liebeskind History of Pain Collection, UCLA
- on the emergence of a new paradigm
Mark Swerdlow, DM
Founder, Intractable Pain Society; Director Emeritus, Northwest
Regional Pain Relief Centre, Manchester
- on the WHO Cancer Pain Relief Programme
June L. Dahl, PhD
Professor, Pharmacology, University of Wisconsin
- on cancer pain initiatives in the US
10:30 - 11 a.m.
Discussion and coffee break
11 - 11:30 a.m.
Concluding Address
Nessa Coyle, MS, RN
Director of Supportive Care, Pain and Palliative Care
Service, Memorial-Sloan-Kettering Cancer Center, New York
- on opioids and pain management in the 21st century
11:30 - 12 noon
Closing discussion
12 noon
Adjournment
This program is supported by an unrestricted educational grant from
Purdue Pharma L.P.
Contact:
History & Special Collections Division
UCLA Louise M. Darling Biomedical Library
12-077 CHS, Box 951798
UCLA
Los Angeles, CA 90095-1798
Tel: 310/825-6940
Fax: 310/825-0465
Marcia Meldrum meldrum@history.ucla.edu
Katharine Donahue kdonahue@library.ucla.edu
Teresa Johnson (Registration) tgj@library.ucla.edu