Supersensitivity
I have a four-part question relating to denervation supersensitivity, and would like some help on any or all parts. Ideally, I'd like original references, but if there are good reviews out there, they would also help. Here goes: 1- When were we first able to measure supersensitivity at the neuronal level? For the longest time denervation supersensitivity was only a postulate based on drug responses; who took us to the next physiological level and when? 2- When did we first get to see receptor changes associated with supersensitivity through powerful microscopes; who took us to this new anatomical level? 3- When was supersensitivity firmly linked to tardive dyskinesia, and by whom? 4- And when did we first get solid evidence that supersensitivity could partly underly the protracted absence of expected symptoms as nigral projections degenerate to a fraction of what they should be in people who would soon exhibit the clinical features of parkinson's disease? That is, when did we discover that supersensitivity could play a role in sparing of function and not just some of the more bizarre effects of brain damage. Thanks, Stan Finger Dep't. of Psychology Washington University St. Louis, MO 63130-4899 USA sfinger@artsci.wustl.edu