Neuroscience News Spring 2009


ARCHIVED EDITION
Published by the UCLA Brain Research Institute
Spring, 2009
Volume 18, No. 2

In this issue:

· The BRI Welcomes Three New Members - Dr. Lara Ray, Dr. Fred Sabb, and Dr. Allan Wu
· Congratulations to Mark Frye, Hui Sun, Wayne Hubbell and Barbara A. Levey
· UCLA Pro-Test - The UCLA Community Stands Up For Biomedical Research 
· Mark Your Calendars (http://www.bri.ucla.edu/bri_calendar)
· 2009 Science Outreach
· Fellowships, Awards & Grants – Opportunities & UCLA T32 neuroscience training grants
· Core Facilities/Resources – Carol Moss Spivak Confocal Imaging Core moved to the CNSI
· Employment – Opportunities/Candidates

    THE BRI WELCOMES THREE NEW MEMBERS

    The Brain Research Institute welcomes its newest members, Dr. Lara Ray, Assistant Professor of Psychology, Dr. Fred Sabb, Assistant Professor of Psychiatry & Biobehavioral Sciences, and Dr. Allan Wu, Assistant Professor of Neurology.

    Lara Ray received a Master of Arts degree in Clinical Psychology, an Interdisciplinary Graduate Certificate in Behavioral Genetics, and a Ph.D. degree in Clinical Psychology from the University of Colorado at Boulder. She then completed an internship in Clinical Psychology (Adult Track) in the Department of Psychiatry and Human Behavior, and a postdoctoral fellowship at the Center for Alcohol and Addiction Studies, at Brown University Medical School. Dr. Ray joined UCLA as Assistant Professor of Psychology (Clinical Area) in July, 2008.

    Dr. Ray’s research focuses on the genetics of addiction. “I am interested in the etiology and treatment of substance use disorders, particularly alcohol abuse and dependence. My program of research focuses on the integration of clinical psychology, pharmacology, and behavioral genetics. I am especially interested in employing experimental designs to answer questions about mechanisms of risk and of treatment response for substance use disorders.”

    Fred Sabb received his Ph.D. degree in Neuroscience from UCLA in 2005. He then completed a two-year postdoctoral fellowship in the Department of Psychology at UCLA as an NIMH fellow. In 2008 he was appointed Assistant Professor of Psychiatry and Biobehavioral Sciences at UCLA.

    Dr. Sabb’s research interest is phenomics, the system-wide study of phenotypes for whole-genome analysis. “My main interests are in implementing high-throughput strategies to represent and refine latent cognitive and behavioral phenotypes used in pursuit of novel genes for neuropsychiatric disorders like schizophrenia, bipolar disorder, and ADHD. In particular, I am interested in the interaction between components of cognitive control, including working memory, response inhibition, and task switching, and how these processes are perturbed in psychiatric disorders. I employ neuro-informatics techniques to build complex phenotypic construct models that can ultimately drive more directed behavioral and neuroimaging experiments. To this end, I am primarily involved in the Consortium for Neuropsychiatric Phenomics, which aims to examine these cognitive phenotypes in pursuit of novel genes for neuropsychiatric disorders.”

    Allan Wu received an M.D. degree from Johns Hopkins School of Medicine in Baltimore, Maryland. He then completed an internship in internal medicine at the Beth Israel Deaconess Medical Center in Boston, followed by a residency in neurology in the Harvard Longwood Neurology Training Program, serving multiple hospitals in the Boston area. Dr. Wu then completed a fellowship in neuromuscular/electromyography in the Department of Neurology at the Lahey Clinic in Burlington, Massachusetts. In 2000, Dr. Wu moved to California, as a fellow in the Division of Movement Disorders in the Department of Neurology at the University of Southern California. In 2001, Dr. Wu was appointed Assistant Professor of Neurology in the Keck School of Medicine at USC. In 2005, Dr. Wu joined UCLA as Assistant Professor of Neurology, and Associate Director of the Transcranial Magnetic Stimulation Laboratory in the Ahmanson-Lovelace Brain Mapping Center.

    Dr. Wu’s primary research interest is the investigation of the brain-behavior relationships that are responsible for the clinical expression of symptoms and signs in patients affected by neurologic disorders, in particular, those patients affected by movement disorders such as Parkinson’s disease (PD). “We are particularly interested in functional changes that occur in the cerebral cortex in response to subcortical dysfunction that can be probed with noninvasive techniques such as transcranial magnetic stimulation (TMS). Current projects include a study of repetitive TMS effects on mood and motor function in atypical parkinsonism; studies of motor cortex stimulation on cortico-striatal function in Parkinson’s disease; studies contrasting discrete and continuous movements in Parkinson’s disease; and studies using both fMRI and TMS to map circuits related to motor learning in stroke and Parkinson’s disease patients.”

    The Brain Research Institute is happy to welcome its newest members.

    CONGRATULATIONS!

    The BRI congratulates the meritorious achievements of Drs. Mark Frye and Hui Sun, Ulrich Batzdorf, Wayne Hubbell, and Barbara Levey.

    Mark Frye and Hui Sun, Assistant Professors of Physiology, have received Early Career Scientist awards from the Howard Hughes Medical Institute. The awards, made to 50 researchers nationwide, are intended to allow scientists to explore their best ideas without worrying about where to find the money to fund their research. Drs. Frye and Sun will each receive, over a six-year appointment, their full salary, benefits and a research budget of $1.5 million. Dr. Frye, by using flies as a subject of study, has dedicated his work to unraveling the neuron-by-neuron code for sight, smell and motor control. He is also studying fly social communication and delving into the genes that control their behavior. Dr. Sun is exploring how Vitamin A, a molecule essential for the eye, brain, immune system, reproductive systems, and developing embryo, gets efficiently transported to highly specific tissue destinations by its carrier protein. He aims to find not-yet-identified signaling receptors that, one day, may provide a means for treating several major human diseases that still remain largely incurable.

    Ulrich Batzdorf, Professor Emeritus of Neurosurgery, is the recipient of the 2009 Byron Cone Pevehouse Distinguished Service Award from the California Association of Neurological Surgeons for his outstanding contributions to clinical, academic and administrative neurosurgery for nearly 40 years, as well as being a great surgeon, mentor and educator. The award is conferred upon a neurosurgeon in California who has served both the community of neurosurgery and medicine in general in an extraordinarily effective and distinguished manner. 

    Wayne Hubbell, Jules Stein Professor of Ophthalmology, and Distinguished Professor of Chemistry and Biochemistry, will receive the Christian B. Anfinsen Award from the Protein Society for his development, application and advocacy of site-directed spin labeling of proteins. The award, sponsored by the Aviv Family Foundation, will be presented to Dr. Hubbell at the 23rd Annual Symposium of the Protein Society in Boston July 25, 2009.

    Barbara A. Levey, Director of UCLA's Interdepartmental Clinical Pharmacology Training Program, has been named the Rosalinde and Arthur Gilbert Foundation Endowed Chair in Interdepartmental Clinical Pharmacology. The Rosalinde and Arthur Gilbert Foundation has pledged $1 million to the UCLA Foundation to fund an endowed chair in clinical pharmacology at the David Geffen School of Medicine, to be held by the director of the training program. The clinical pharmacology program at UCLA studies issues related to drug interactions, the individual's response to drugs and how different ethnicities metabolize drugs. The chair's focus will be to catalyze the crucial work of UCLA's current program by augmenting research in this emerging discipline while reinforcing the importance of clinical pharmacology education at the Geffen School of Medicine, which is internationally recognized for excellence in the field.

    Warm congratulations to Drs. Mark Frye and Hui Sun, Ulrich Batzdorf, Wayne Hubbell and Barbara Levey from the staff, students and faculty of the Brain Research Institute!

    UCLA PRO-TEST

    The UCLA Community Stands Up For Biomedical Research 

    Students, faculty and staff at UCLA have formed a group to demonstrate their support for life-saving medical research, and as a sign of solidarity towards those scientists who have been the victims of recent animal rights extremism. California has become the center of anti animal-research extremism in the US, with anti-biomedical research groups and underground terrorist organizations putting on regular demonstrations against laboratories and scientists across the state. There have also been numerous incidents of extremism by groups such as the Animal Liberation Brigade (ALB) and the "Justice Department." UCLA Pro-Test founder David Jentsch was the victim of such an attack, when his car was firebombed and his personal safety threatened, by the ALB. 

    The campus movement, UCLA Pro-Test, organized a demonstration on Wednesday, April 22nd, to support medical research; it coincided with the "World Week for Animals in Laboratories" rally organized by various anti-research extremist groups. The UCLA Pro-Test demonstration paralleled the 2006 demonstrations by the UK student organization Pro-Test, which opened the public debate on animal research in the UK and contributed to the downfall of animal rights activism in the UK. One of UK Pro-Tests founders, Tom Holder, was on hand at the Los Angeles rally to show his support for UCLA’s efforts and to emcee the event.

    UCLA faculty and students conducting cutting-edge research on the biology of mental disorders and treatments for AIDS and pediatric afflictions have been the victims of increasingly vicious and hateful attacks because of the direct or indirect involvement of animals in their studies. Animal research is crucial for the development of most medical breakthroughs, including the development of insulin and penicillin and the creation of treatments for leukemia and breast cancer. Without such methods, medical progress would be severely impaired.

    "Year after year, anti-biomedical research activities in Los Angeles (primarily directed against UCLA faculty and students) have grown (in size and methodology). They have written terrible and hateful lies about us. They have maligned us and our University. They have scared adults and children alike at home. They destroyed our property and sense of security and threatened some of our lives. Their momentum is building. All this while, we haven't risen up as a group and said 'enough is enough.' The time has come." - David Jentsch. "It's very exciting that students, scientists, patients and members of the public on both sides of the Atlantic are willing to stand up in support of the continuing importance of animal based research." - Laurie Pycroft, founder of the UK Pro-Test movement.

    MARK YOUR CALENDARS

    The Eight Annual Southern California Learning & Memory Symposium
    Neuroscience Research Building Auditorium, UCLA, Wednesday, June 3, 2009

    8:30 Continental Breakfast
    9:00 Welcome and Opening Remarks
    Alcino Silva, Ph.D., Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, University of California, Los Angeles
    Chair: Michael Fanselow, Ph.D., Department of Psychology, University of California, Los Angeles
    9:05 The Role of Medial Temporal Lobe Subregions in Human Memory
    Barbara Knowlton, Ph.D., Behavioral Neuroscience, Department of Psychology, University of California, Los Angeles
    9:35 Pattern Separation in the Human Hippocampus
    Craig Stark, Ph.D., Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning & Memory, University of California, Irvine
    10:05 Toward a Hippocampal Neural Prosthesis: Implantable Biomimetic Microelectronics to Restore Lost Memory
    Theodore Berger, Ph.D., David Packard Professor of Engineering, Professor of Biomedical Engineering and Neuroscience, University of Southern California, Los Angeles
    10:35 Coffee Break
    Chair: David Glanzman, Departments of Physiological Science, and Neurobiology, University of California, Los Angeles
    11:00 Memory in Birdsong Learning 
    Mark Konishi, Ph.D., Bing Professor of Behavioral Biology, Division of Biology, California Institute of Technology, Pasadena, California
    11:30 Phase Coding in the Hippocampal Memory System: Analog Synthesis of Spatial Memory Signals from Theta Oscillations
    H. Tad Blair, Ph.D., Behavioral Neuroscience, Department of Psychology, University of California, Los Angeles
    12:00 Neonatal Imprinting; Plastic Mechanisms Regulate Innate Behavior
    Lisa Stowers, Ph.D., Department of Cell Biology, The Scripps Research Institute, La Jolla, California
    12:30 Lunch Break
    Chair: Alcino Silva, Ph.D., Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, University of California, Los Angeles
    2:00 The Biochemistry of Learning: The Calpain Hypothesis Revisited
    Michel Baudry, Ph.D., Department of Biological Sciences, University Of Southern California, Los Angeles
    2:30 Zebrafish as a Model for Sleep and Sleep Disorders 
    David Prober, Ph.D., Division of Biology, California Institute of Technology, Pasadena, California
    3:00 Dissecting the Contribution of Individual Cortical Layers to Behavior
    Tansu Celikel, Ph.D., Laboratory of Neural Circuits and Plasticity, Department of Biological Sciences, University of Southern California, Los Angeles
    3:30 Coffee Break
    Chair: Kelsey Martin, M.D., Ph.D., Departments of Psychiatry & Biobehavioral Sciences, and Biological Chemistry, University of California, Los Angeles
    4:00 Biochemical Networks Controlling Synaptic Plasticity
    Mary Kennedy, Ph.D., Alan and Lenabelle Davis Professor of Biology, Division of Biology, California Institute of Technology, Pasadena, California
    4:30 The Perirhinal Cortex is Critical for Memory Function, But What About Visual Perception?
    Robert Clark, Ph.D., Department of Psychiatry, School of Medicine, University of California, San Diego; VA San Diego Healthcare System
    5:00 Sleep and Pavlovian Fear Conditioning
    Stephan Anagnostaras, Ph.D., Department of Psychology, and the Neurosciences Program, University of California, San Diego
    5:30 Reception— Gonda Building First Floor Conference Room, 1357

    JOINT SEMINARS IN NEUROSCIENCE

    The Joint Seminars in Neuroscience series will resume Winter quarter beginning January 6, 2009. Please mark your calendars and plan to join us every Tuesday at 4:00 p.m. in the Neuroscience Research Building Auditorium.

    The Joint Seminars in Neuroscience are sponsored by the Brain Research Institute, the Semel Institute for Neuroscience & Human Behavior, and the David Geffen School of Medicine at UCLA.

    Joint Seminars in Neuroscience 
    Fall Quarter 2009 Preview

    Tuesday, September 29, 2009
    Pat Levitt, Ph.D., Director, Zilkha Neurogenetic Institute; Provost Professor of Neuroscience, Psychiatry & Pharmacy; Chair, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California
    (Host: Chris Evans: cevans@ucla.edu)

    Tuesday, October 6, 2009
    Keqiang Ye, Ph.D., Associate Professor 
    Pathology & Laboratory Medicine, Neuroscience Graduate Program, and Pharmacology Graduate Program, Emory University School of Medicine, Atlanta, Georgia
    (Host: Yi Sun: YSun@mednet.ucla.edu)

    Tuesday, October 13, 2009
    Fritjof Helmchen, Ph.D., Department of Neurophysiology, Brain Research Institute, University of Zurich, Switzerland 
    (Host: Carlos Portera-Cailliau: CPCailliau@mednet.ucla.edu)

    Tuesday, October 20, 2009
    No JSN- SfN Meeting, Chicago, Illinois

    Tuesday, October 27, 2009
    Wade Regehr, Ph.D., Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
    (Host: Tom Otis: OtisT@mednet.ucla.edu)

    Tuesday, November 3, 2009
    A. Leslie Morrow, Ph.D., Associate Director, Bowles Center for Alcohol Studies; Professor 
    Departments of Psychiatry and Pharmacology, University of North Carolina at Chapel Hill
    (Host: David Jentsch: Jentsch@psych.ucla.edu)

    Tuesday, November 10, 2009
    Kristin Scott, Ph.D., Department of Molecular and Cell Biology, University of California, Berkeley
    (Host: Mark Frye: frye@physci.ucla.edu)

    Tuesday, November 17, 2009 
    The Poster Session Distinguished Lecturer
    George Koob, Chair, Committee on The Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California
    (Host: Chris Evans: cevans@ucla.edu)

    Tuesday, November 24, 2009
    The Distinguished Postdoctoral Fellow in Neuroscience Lecture- Speaker to be Determined
    (Host: Bernard Balleine: Balleine@pysch.ucla.edu)

    Tuesday, December 1, 2009
    Torkel Hafting or Marianna Fyhn, Department of Physiology, University of California, San Francisco
    (Host: Tad Blair: blair@psych.ucla.edu)

    2009 SCIENCE OUTREACH

    The BRI sponsors multiple scientific and educational outreach programs throughout the year for the greater Los Angeles community. Events include school visits, tours and demonstrations, Brain Awareness Week tours, and sponsoring prizes at the California State Science Fair. This year, BRI Director, Chris Evans, BRI Outreach Program Director, Joseph Watson, and a few neuroscience graduate students will participate in judging the presentations at the California State Science Fair. The BRI will present awards to junior and senior students from all over California for excellent science projects in all areas of neuroscience, from molecules to mind.

    FELLOWSHIPS, AWARDS & GRANTS

    Alfred P. Sloan Foundation
    2009 Sloan Research Fellowships


    The Sloan Research Fellowship Program was established in 1955 to provide support and recognition to young scientists, often in their first university faculty appointments. The award helps tenure track junior faculty at colleges or universities set up laboratories and establish their independent research projects in the following fields: physics, chemistry, mathematics, neuroscience, economics, computer science, and computational and evolutionary molecular biology. These highly competitive awards carry high prestige due to the careful nature of the selection process and the outstanding quality of past recipients, including many UCLA researchers.

    Candidates for the Sloan Research Fellowships must hold the Ph.D. (or equivalent) in chemistry, physics, mathematics, computer science, economics, neuroscience, computational and evolutionary molecular biology, or in a related interdisciplinary field, and normally must be no more than six years from completion of the most recent Ph.D. (or equivalent) as of the year of nomination.

    Alfred P. Sloan Foundation
    2009 Sloan Industry Studies Fellowships


    The Sloan Industry Studies Fellowship Program was launched in 2004 to support the development of research in industry studies by promoting research cooperation between academics and industry in order to understand the complex influences that shape industrial enterprises. They are modeled after the Sloan Research Fellowships.

    Candidates for the Sloan Industry Studies Fellowships must hold the Ph.D. (or equivalent) in economics, management, engineering, political science, sociology, or in a related or interdisciplinary field, and normally must be no more than six years from completion of their most advanced degree as of the year of nomination.

    For both programs: Circumstances, such as a change of field, child rearing, military service, or a faculty appointment for less than two years, will be taken into consideration; Candidates in all eligible fields are normally below the rank of associate professor and do not hold tenure, but these are not strict requirements; Funds may not be used to augment an existing full-time salary or for indirect or overhead charges by the Fellow’s institution.

    To Apply: The application procedure for both fellowship programs is posted on the Sloan website (http://www.sloan.org/fellowships) where the nomination forms may also be downloaded. There is no limit to the amount of eligible nominations that UCLA may submit. For both programs, candidates must be nominated by department heads or other senior scholars. Nomination forms and all supporting materials are due to the sponsor by the deadline dates.


    The Whitehall Foundation -- Grants for Research in Neurobiology
    The Whitehall Foundation is accepting applications throughout the year for grants to support basic research in neurobiology, especially on how the brain's sensory, motor, and other complex functions relate to behavior. 
    Candidates eligible for these grants include tenured or tenure-track professors at accredited American institutions.

    Deadlines for letters of intent to apply are due by January 15, April 15, and October 1; the three deadlines for applications during the year are June 1, September 1, and February 15.

    The total amount and number of awards is not specified, however, the amount of individual awards range from $30,000 to $75,000 each year for up to three years. View the full announcement: http://www.whitehall.org/grants.


    T32/T90 Neuroscience Training Grants at UCLA

    A number of training grants offer support to neuroscience graduate students and postdoctoral fellows. Appointments are generally made each year at the beginning of the project period, but can be made during the entire year. All inquiries and applications must be submitted by the faculty mentor. The BRI frequently sends out “Call for Nominations,” so please watch for announcements. Mike Levine is submitting a T32 program to fund 1st and 2nd year Neuroscience students across the IDP, Neurobiology and Psychology programs which if successful will increase cross-talk among our training programs. 

    Of note is that the BRI has recently instated a committee (The BRI Committee for Enhancement of Neuroscience Training Programs) to determine where the BRI can help in the operation and submission of NIH T32 grants. The Chair of the Committee is the BRI Associate Director for Research Dr Bernard Balleine and several new initiatives regarding program recruitment, faculty information databases and ethics training will be put in place during the coming months.

    T32/T90 Neuroscience Training Grants at UCLA

    Grant Number

    PI Name

    Project Title

    Number Pre/Post

    Appoint.
    Period

    5T32HD007228

    Arnold, Arthur

    Neuroendocrinology, Sex Differences, and Reproduction

    5 Pre
    2 Post

    5/1-4/30

    5T32NS007449

    Chesselet, Marie-Francoise

    Training Program in Neural Repair     

    2 Pre
    2 Post

    7/1-6/30

    5T90DA022768

    Cohen, Mark

    Comprehensive Training in Neuroimaging Fundamentals and Applications   

    5 Pre

    9/30-7/31

    5T32HD007032

    De Vellis, Jean

    Mental Retardation and Developmental Disabilities

    3 Pre
    5 Post

    5/1-4/30

    5T32HD007549

    Devaskar, Sherin

    Training in Neonatal and Developmental Diseases

    7 Post

    5/1-4/30

    5T32MH015750

    Dunkel Schetter, Christine

    Biobehavioral Issues in Physical and Mental Health

    3 Pre
    2 Post

    7/1 or 9/1

    5T32MH015795

    Fanselow, Michael

    Training in Behavioral Neuroscience  

    3 Pre
    2 Post

    7/1-6/30

    1T32NS058280

    Feldman, Jack

    Training Program in Neural Microcircuits

    2 Pre
    2 Post

    1/1-12/31

    5T32NS048004

    Freimer, Nelson

    Training Grant in Neurobehavioral Genetics          

    4 Post

    7/1-6/30

    5T32MH073526

    Geschwind, Daniel

    Training Grant in Neurobehavioral Genetics

    4 Pre

    6/1-5/31

    2T32MH019384

    Glanzman, David

    Training Program in Molecular and Cellular Neurobiology

    4 Pre

    10/1-9/30; 
    7/1-6/30 in 09

    2T32MH019535

    Hinkin, Charles

    Neuropsychology AIDS Fellowship

    3 Post

    Start 7/1 thru 9/1

    5T32MH019925

    Irwin, Michael

    Post-Graduate Training Program in Psychoneuroimmunology and Mental Disorders

    3 Post
    2 yrs

    7/1-6/30

    5T32MH017140

    Leuchter, Andrew

    Research Training: Psychobiological Sciences

    5 Post

    7/1-6/30

    1T32DA024635

    London, Edythe

    Training Program in Translational Neuroscience of Drug Abuse

    3 Pre

    4/1-3/31

    5T32GM067555

    Monbouquette, Harold

    Biotechnology Training in Biomedical Sciences

    5 Pre

    7/1-6/30

    5T32NS007101

    O'Dell, Thomas

    Cellular Neurobiology

    4 Post

    7/1-6/30

    2T32DA007272

    Rawson, Richard

    UCLA Drug Abuse Research Training Center

    2 Pre
    3 Post

    1 yr--Varies

    5T32GM065823

    Tidball, James

    Training in Molecular, Cellular & Integrative Physiology

    4 Pre

    Oct 1
    1 year appt

    5T32EY007026

    Travis, Gabriel

    Vision Research Training Grant

    6 Pre
    2 Post

    Varies

    CORE FACILITIES, RESOURCES AND SERVICES

    Bioscience Cores at UCLA (http://www.bioscience.ucla.edu)

    BRI Cores:
    Carol Moss Spivak Cell Imaging Facility*
    Confocal Microscopy
    For information, contact: 
    Dr. Matt Schibler X59783 (310-825-9783)
    E-mail: mschibler@mednet.ucla.edu

    Electron Microscopy and Specimen Preparation
    For information, contact:
    Marianne Cilluffo, x59848 (310-825-9848)
    E-mail: mariannc@ucla.edu

    Microscopic Techniques and Histological Preparation
    For information, contact:
    Marianne Cilluffo, x59848 (310-825-9848)
    E-mail: mariannc@ucla.edu

    * The BRI Carol Moss Spivak Cell Imaging Core has moved in with the Advanced Light Microscopy Core, directed by Shimon Weiss and Laurent Bentolila. After a decade of operation on the first floor of the Gonda, joining these two facilities will result in a technically sophisticated confocal core on campus with considerably up-graded equipment and increased capacity compared to our current facility. The facility will have enhanced capability for FRET, FLIM, FCS, 2-photon microscopy and small animal imaging (zebrafish, flies and C. elegans). This core is centrally located on the B floor of the new California Nanosystems Institute (CNSI) and will continue to be available to all faculty laboratories at UCLA. Dr. Matt Schibler who has admirably run the BRI core since its inception will continue to train users and run/maintain equipment in the new facility. For concerned regular users of the core please contact Matt if you require details of instrument availability in March and April; the exact date for completion of the move is not yet established. There should be little downtime since most of the new instruments are up and running. You may need to learn slight differences between the new confocals even though they run on the same software. At this time no increase in core usage fees is anticipated.

    Other Cores:
    Biopolymer Laboratory
    Peptide synthesis, amino acid analysis, Edman sequencing, mass spectrometry.
    For information contact:
    Margaret Condron x62088 (310.206.2088)
    E-mail: condron@ucla.edu

    Pasarow Mass Spectrometry Laboratory
    For information, contact:
    Dr. Kym Faull X67881 (310-206-7881)
    E-mail: faull@chem.ucla.edu


    Research Resources Available:
    Postmortem Human Frozen Brain Tissue and Matched Cerebrospinal Fluid (CSF) and Blood are Available for Scientists to Search for Etiopathogeneses of Human Disease.

    The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank, located at VA West Los Angeles Healthcare Center, maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid (CSF) from patients with neurological diseases (including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's Disease, progressive supranuclear palsy, schizophrenia, stroke/CVA and other less common diseases). Full inventory is available upon request. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology.

    Special features of the Bank are as follows:

    1). Serial digital images of coronal sections (7 mm thick and obtained before quick freezing) are available for selecting samples to be studied.
    2). Microscopic neuropathology is available on each dissected sample and the dissected sample's localization is sketched on the gross coronal section image from which it came.
    3). Plaques of demyelination are classified as active, chronic active or inactive, and a shipment includes adjacent normal appearing white and nearby gray matter from the same case (they serve as a type of control).
    4). Ice artifact is minimized and it does not interfere with in situ hybridization or in situ PCR or immunocytochemistry.
    5). Tissue samples have been used for harvesting enough mRNA for microarray assay plates.
    6). CSF cells and cell-free CSF are available pre- and postmortem as is serum, plasma and buffy coats. They are stored quick frozen (full inventory is available upon request).

    The Bank is supported by NIH (NINCDS/NIMH), the National Multiple Sclerosis Society and Veterans Affairs West Los Angeles Healthcare Center. For further information on tissues/CSF available and how to access them, contact:

    Wallace W. Tourtellotte, M.D., Ph.D.
    Neurology Research (127A)
    VA West Los Angeles Healthcare Center
    11301 Wilshire Blvd
    Los Angeles, CA 90073
    (310) 268_4638; fax: (310) 268_4638
    E-mail: wtourtel@ucla.edu
    web: www.loni.ucla.edu/~nnrsb/NNRSB


    Alzheimer's Disease Brain Tissue and CSF
    The Neuropathology Laboratory at UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses (including progressive supranuclear palsy, Parkinson's disease, fronto-temporal dementia), as well as control materials removed in a similar fashion from patients who are neurologically normal. Tissues are maintained as part of the NIA-funded Neuropathology Core functions of the UCLA Alzheimer's Disease Center. These tissues/fluids are available as a resource to investigators in any discipline. Pilot studies using the tissues/CSF to examine biomolecules that are of known importance in animal models and suspected significance in human neurodegenerative conditions are particularly encouraged. Every attempt will be made to provide research materials for worthwhile projects in a timely fashion. For further information on tissues/CSF available and how to access them, contact:

    Dr. Harry Vinters, Section of Neuropathology
    UCLA Medical Center, CHS 18-170
    Los Angeles, CA 90095-1732
    Phone: 310-825-6191; Fax: 310-206-8290
    E-mail: hvinters@mednet.ucla.edu

    EMPLOYMENT OPPORTUNITIES

    NIH-funded Postdoctoral Position-Neurophysiology

    A Postdoctoral position is available in the area of Neurophysiology, starting late winter/ early spring. The laboratory studies the cell physiology of gonadotropin releasing hormone (GnRH) neurons within an intact neural network during embryonic development using transgenic zebrafish. Candidates must have expertise in electrophysiology; optical imaging experience is a plus. Three years of NIH funding is available; salary is commensurate with experience. For additional information about the lab, refer tohttp://www.uclaaccess.ucla.edu/UCLAACCESS/web/Faculty.aspx?ri=166. Please send curriculum vitae along with the names and contact information for references to: Dr. Nancy Wayne; nwayne@mednet.ucla.edu.

    EMPLOYMENT CANDIDATES

    The BRI regularly receives letters and resumes from people looking for work in the field of neuroscience. Below is an abbreviated list of the candidates and the type of work they seek. Copies of their resumes are often available in our editorial office. If you are interested in one or more of these individuals, please contact them directly, or call the editorial office at x56055.

    Nadeeka Dias is currently a senior at The University of Texas at Austin. She will graduate with a B.S. in chemistry; however, she is planning to shift her focus to neuroscience for graduate study. After working in multiple research labs during her undergraduate years, she has recognized how much better she learns and retains in a laboratory setting. This is why she is looking to gain some firsthand research experience in this field. She is currently looking for a summer research position, and would love the opportunity to learn more about neuroscience at the Brain Research Institute. She has a good amount of experience in undergraduate research varying from inorganic chemistry and biochemistry to anesthesia, which is detailed in her CV (available from the editorial office). She is willing to volunteer in a lab; experience is what she is most interested in acquiring. She is available from (June 15-Aug 28), and can work from 10am-5pm or whenever needed. If interested, please contact Nadeeka directly at E-mail: nadeekadias@gmail.com.

    Jordan Hoffman is a senior student in Psychological & Brain Sciences at Johns Hopkins University and is looking for a research assistant position beginning in June, 2009. Currently, he is working part-time for the Johns Hopkins Center of Aging and Health under Dr. Michele Carlson, whose studies focus on dementia and AD prevention. For the past three years Jordan has been committed to the research of the well-being of older adults enrolled in the Experience Corps program. The E.C. program researches older adults that enter the school system as reading tutors. As part of his duties, he performed an extensive interview evaluation of older adults before and after the volunteer intervention to test for any benefits in mental, physical and social well-being. He also has experience in many different aspects of research including recruitment, one-on-one subject evaluations (cognitive, physical, social), phone interviews, data analysis, data entry (STATA, MS Word, MS Excel) among others. He has been using FSL imaging software to perform fMRI skull stripping, a procedure to improve images so that they may be multiplied and further analyzed. He has also used FSL to perform volumetric analysis of the hippocampi of older adults involved in the Experience Corps program. Other research related experiences can be found in my CV. He is able to offer a 2-3 year commitment beginning in June 2009. Jordon has had several years of research experience (CV available in editorial office). If interested, please contact Jordon directly at: E-mail:jhoffm31@jhu.edu.

    Diego Gabriel Ogando, Ph.D., would like to obtain a postdoctoral position. He received his Ph.D. in biological sciences from the University of Buenos Aires, Argentina. His research interests are in the field of molecular biology. In his most recent postdoctoral position, he studies the genetics of retinal degeneration (death of photoreceptors) models in mice. A more detailed description of his research efforts and his CV are available in the editorial office. Please contact Dr. Ogando directly at E-mail: dieogando@gmail.com.

    Carina Sohaili is currently a junior at George Washington University majoring in psychology. She took her first cognitive neuroscience class last semester and became extremely passionate and stimulated by the field and has decided to concentrate in cognitive neuroscience and will be taking the required classes next year. Last semester she took research methods and was required to write a mock research report on a topic of interest. She chose to do her report on the fusiform face area and how the area processes and represents faces. The report focused on whether the fusiform face area is domain specific and devoted exclusively to recognizing face stimuli or if the fusiform face area performs perceptual discriminations through a holistic process based on expertise. This topic interested her because understanding the role of the fusiform face area in visual object recognition could provide a greater understanding of how the brain processes other information as well. Carina would like to volunteer in order to gain a better understanding of different areas within the cognitive neuroscience field and/or clinical psychology. She is interested in going to graduate school in cognitive neuroscience and would like to use this summer to get a better grasp on areas of study in cognitive neuroscience. She is available two days a week Monday-Friday in the afternoons. She is taking a class at UCLA in the mornings and will have to get a paid job three days a week, but can work around a faculty mentor’s schedule. If interested in volunteer help, please contact Carina directly at: csohaili@yahoo.com.


    IMPORTANT NOTE: 

    Neuroscience News serves as the primary vehicle for disseminating information to the UCLA neuroscience community. It is published solely on the Brain Research Institute’s web site http://www.bri.ucla.edu and distributed to the BRI Calendar E-mail list. Please submit all information to the BRI editorial office, E-maillmaninger@mednet.ucla.edu, or call extension 56055 or 55061.

    Editor: Linda Maninger