for drink could be in the genes
By Roger Highfield
gene mutation that increases the likelihood of becoming
drunk on just one drink has been discovered.
Scientists were studying rats but believe that tolerance
levels to alcohol may be genetically wired in people too
and could eventually help identify children and adults
at higher risk of developing a drink problem.
interferes with how brain cells communicate with one another,
resulting in a lack of co-ordination, grogginess, impaired
memory and loss of inhibitions associated with drunkenness.
researchers have been unable to pinpoint how alcohol causes
this disruption in the brain.
scientists at the David Geffen School of Medicine at UCLA
have deciphered how a naturally occurring gene mutation
in rats' brains lowers the animals' tolerance to alcohol,
leading to rapid and acute intoxication after the equivalent
of one drink. The same effect is highly likely to be seen
study, published yesterday in the journal Nature Neuroscience,
is the first to identify how the gene variation influences
one of the main messenger chemicals in the brain.
of the authors, Prof Richard Olsen, said: "If we
understand the action of alcohol at the cellular and molecular
level, it is helpful in treating the harmful effects that
alcohol may have."
Original source: http://news.telegraph.co.uk